Valenzuela Michael J, Jones Megan, Wen Wei, Rae Caroline, Graham Scott, Shnier Ronald, Sachdev Perminder
Neuropsychiatric Institute, The Prince of Wales Hospital, Euroa Centre, Randwick, NSW 2031, Australia.
Neuroreport. 2003 Jul 18;14(10):1333-7. doi: 10.1097/01.wnr.0000077548.91466.05.
Accumulating epidemiological evidence supports the notion of brain reserve, but there has been no investigation of neurobiological change associated with brief mental activation training in humans. Healthy older individuals were therefore investigated with magnetic resonance spectroscopy (MRS) in different brain regions before and after 5 weeks of focused memory training. Recall of a test-word list of > 23 items was achieved accompanied by elevation of creatine and choline signals in the hippocampus. Those at risk for neural dysfunction, as indicated by lower neurometabolites at baseline, demonstrated the largest MRS increases after training. Biochemical changes related to cellular energy and cell-membrane turnover were found to increase after structured memory exercises and were limited to the medial temporal lobe.
越来越多的流行病学证据支持大脑储备的概念，但尚未有关于人类短期精神激活训练相关神经生物学变化的研究。因此，我们对健康的老年人进行了研究，在为期5周的集中记忆训练前后，使用磁共振波谱（MRS）对不同脑区进行检测。结果显示，在回忆超过23个项目的测试单词列表时，海马体中的肌酸和胆碱信号升高。那些在基线时神经代谢物水平较低，表明有神经功能障碍风险的人，在训练后MRS增加幅度最大。研究发现，与细胞能量和细胞膜更新相关的生化变化在进行结构化记忆练习后增加，且仅限于内侧颞叶。
