Hendrikse Jeroen, Lu Hanzhang, van der Grond Jeroen, Van Zijl Peter C M, Golay Xavier
Department of Radiology, University Medical Center, Utrecht, The Netherlands.
Magn Reson Med. 2003 Aug;50(2):429-33. doi: 10.1002/mrm.10525.
Estimation of cerebral blood flow (CBF) in functional perfusion imaging could benefit from a method capable of separating effects of arterial arrival time and trailing edge. To accomplish this, the transfer insensitive labeling technique (TILT) was combined with a train of 13 consecutive acquisitions, called TURBO-TILT. Visual activation maps obtained at 13 postlabeling delay times (TI) showed a spatial shift from regions surrounding the arterial vasculature at short TI to brain parenchyma at longer delay times. High baseline CBF and short arrival times were found for the voxels with maximum activation at short TI (<1200 ms), while CBF values (43 ml / 100 g tissue/min) and its increase upon activation (55%) at longer TI were in agreement with literature data on regional cerebral perfusion.
在功能灌注成像中，估计脑血流量（CBF）可能受益于一种能够分离动脉到达时间和后沿效应的方法。为实现这一点，将转移不敏感标记技术（TILT）与一系列连续13次采集相结合，称为TURBO-TILT。在13个标记后延迟时间（TI）获得的视觉激活图显示，在短TI时从围绕动脉血管的区域向长延迟时间时的脑实质出现空间偏移。在短TI（<1200毫秒）时具有最大激活的体素具有高基线CBF和短到达时间，而在较长TI时的CBF值（43毫升/100克组织/分钟）及其激活时的增加（55%）与关于局部脑灌注的文献数据一致。
