Black Robin M, Muir Bob
J Chromatogr A. 2003 Jun 6;1000(1-2):253-81. doi: 10.1016/s0021-9673(03)00183-3.
The analysis of chemical warfare agents and their degradation products is an important component of verification of compliance with the Chemical Weapons Convention. Gas and liquid chromatography, particularly combined with mass spectrometry, are the major techniques used to detect and identify chemicals of concern to the Convention. The more polar analytes, and some of the more reactive or highly volatile agents, are usually derivatised to facilitate chromatography, and to impart properties beneficial for detection. This review focuses on derivatisation reactions used in the chromatographic analysis of chemical warfare agents, their degradation products and metabolites.
化学战剂及其降解产物的分析是《化学武器公约》履约核查的重要组成部分。气相色谱法和液相色谱法，尤其是与质谱联用，是用于检测和识别该公约所关注化学品的主要技术。极性较强的分析物以及一些反应性更强或挥发性更高的战剂，通常要进行衍生化处理，以利于色谱分析，并赋予有利于检测的特性。本综述着重介绍化学战剂、其降解产物和代谢物色谱分析中所使用的衍生化反应。
