Aberg Peter, Nicander Ingrid, Holmgren Ulf, Geladi Paul, Ollmar Stig
Division of Medical Engineering, Karolinska Institutet, Huddinge, Sweden.
Skin Res Technol. 2003 Aug;9(3):257-61. doi: 10.1034/j.1600-0846.2003.00017.x.
BACKGROUND/AIMS: Purpose of this investigation was to assess benign pigmented cellular nevus (BEN), basal cell carcinoma (BCC), dermatofibroma (DER), dysplastic nevus (DYS), and seborrheic keratoses (SEB) using in vivo non- invasive electrical impedance technique.
Electrical impedance was measured at 258 BEN, 34 BCC, 17 DER, 35 DYS, and 26 SEB lesions. Controls were measured at healthy skin close to the lesions. The impedance was measured between 1 kHz and 1 MHz at five depth settings. After the impedance measurements the lesions were histopathologically diagnosed. The impedance spectra were parameterized to four indices prior to the statistical analysis of the data.
There were significant differences between the lesions and their controls for BEN (P < 0.001), BCC (P < 0.001), DYS (P < 0.01), and SEB (P < 0.01).
There are clear statistical differences between impedance of common lesions and control skin. With some further developments, the impedance technique can be useful as a diagnostic decision support tool for skin cancer assessment.
背景/目的：本研究的目的是使用体内非侵入性电阻抗技术评估良性色素细胞痣（BEN）、基底细胞癌（BCC）、皮肤纤维瘤（DER）、发育异常痣（DYS）和脂溢性角化病（SEB）。
对258个BEN、34个BCC、17个DER、35个DYS和26个SEB病变进行电阻抗测量。在病变附近的健康皮肤上进行对照测量。在五个深度设置下，在1 kHz至1 MHz之间测量阻抗。在进行阻抗测量后，对病变进行组织病理学诊断。在对数据进行统计分析之前，将阻抗谱参数化为四个指标。
BEN（P < 0.001）、BCC（P < 0.001）、DYS（P < 0.01）和SEB（P < 0.01）的病变与其对照之间存在显著差异。
常见病变的阻抗与对照皮肤之间存在明显的统计学差异。随着进一步的发展，阻抗技术可作为皮肤癌评估的诊断决策支持工具。
