Glickman Yaël A, Filo Orna, David Magda, Yayon Avner, Topaz Moris, Zamir Bosmat, Ginzburg Alexander, Rozenman Dganit, Kenan Gad
TransScan Medical Ltd, PO Box 786, 10550 Migdal Haemek, Israel.
Skin Res Technol. 2003 Aug;9(3):262-8. doi: 10.1034/j.1600-0846.2003.00022.x.
BACKGROUND/AIMS: Skin cancer diagnosis depends, to a great extent, on visual inspection and histopathological examination of excised tissues. The aim of this study is to evaluate the ability of electrical impedance scanning to differentiate between benign and malignant skin lesions.
A preclinical study was conducted on 40 nude mice injected subcutaneously with a human melanoma strain. Impedance measurements were recorded every week to correlate electrical changes with tumor growth and histological findings. A clinical study was also performed on 178 human suspicious skin lesions before excision. The impedance measurements were correlated to the histopathological results.
Normalized conductivity and capacitance, recorded on growing skin tumors in nude mice, were shown to change relative to lesion size. Necrosis, present in most of the larger lesions, was associated with a decrease in the electrical conductivity. Similar electrical parameters were used to classify human melanoma lesions with 92% sensitivity and 67% specificity. In addition, four out of five BCC lesions were correctly diagnosed. Moreover, dysplastic lesions were diagnosed with 91% sensitivity and 59% specificity. For comparison, physicians diagnosed melanoma lesions with 75% sensitivity and 87% specificity and dysplastic lesions with 46% sensitivity and 80% specificity.
The animal study showed that electrical impedance measurements reflect morphological changes related to the growth of a cancerous skin lesion. These findings are in agreement with a preliminary clinical study. Electrical Impedance Scanning can therefore be considered as an objective and non-invasive tool for differentiation between benign and malignant skin lesions.
背景/目的：皮肤癌的诊断在很大程度上依赖于对切除组织的目视检查和组织病理学检查。本研究的目的是评估电阻抗扫描区分良性和恶性皮肤病变的能力。
对40只皮下注射人黑色素瘤菌株的裸鼠进行临床前研究。每周记录阻抗测量值，以将电学变化与肿瘤生长及组织学结果相关联。还对178例人类可疑皮肤病变在切除前进行了临床研究。将阻抗测量结果与组织病理学结果相关联。
在裸鼠生长的皮肤肿瘤上记录的归一化电导率和电容显示出相对于病变大小的变化。大多数较大病变中存在的坏死与电导率降低有关。使用类似的电学参数对人类黑色素瘤病变进行分类，敏感性为92%，特异性为67%。此外，五分之四的基底细胞癌病变被正确诊断。此外，发育异常病变的诊断敏感性为91%，特异性为59%。相比之下，医生诊断黑色素瘤病变的敏感性为75%，特异性为87%，诊断发育异常病变的敏感性为46%，特异性为80%。
动物研究表明，电阻抗测量反映了与皮肤癌性病变生长相关的形态学变化。这些发现与一项初步临床研究一致。因此，电阻抗扫描可被视为区分良性和恶性皮肤病变的一种客观且非侵入性的工具。
