Pallua N, Schneider W
Klinik für Plastische, Hand- und Wiederherstellungschirurgie, Medizinische Hochschule Hannover im Oststadtkrankenhaus.
Unfallchirurg. 1992 Dec;95(12):641-3.
Candida sepsis is a very serious complication in severely burned patients. This mainly affects patients whose immune system is weakened by illness and/or by drugs. Often diagnosis is difficult because candida sepsis occurs after an initial infection, but therapy is always difficult. Good fungicidal drugs are available, but their side effects limit their effectivity. Two severely burned patients who were suffering from a gram-negative sepsis confirmed by clinical and laboratory data developed candida sepsis. Conventional therapy failed, and both patients suffered from renal failure with constantly high candida-latex-antigen titre. By means of the liposomal encapsulated amphotericin B, which has the same fungicidal effect as amphotericin B, but without its limiting side effects, both, patients could be saved. The kidneys functioned as normal again, the laboratory findings were normal when the patients were discharged.
念珠菌败血症是重度烧伤患者非常严重的并发症。这主要影响免疫系统因疾病和/或药物而减弱的患者。通常诊断很困难，因为念珠菌败血症发生在初始感染之后，但治疗总是很棘手。虽然有有效的杀真菌药物，但它们的副作用限制了其有效性。两名经临床和实验室数据确诊患有革兰氏阴性菌败血症的重度烧伤患者发生了念珠菌败血症。常规治疗失败，两名患者均出现肾衰竭，念珠菌乳胶抗原滴度持续居高不下。通过脂质体包裹的两性霉素B，其具有与两性霉素B相同的杀真菌作用，但没有其限制性副作用，两名患者均得以挽救。肾脏功能恢复正常，患者出院时实验室检查结果正常。
