单次剂量阿奇霉素对经鼓膜穿刺术作为基线检查的儿童急性中耳炎的治疗效果。
Efficacy of single-dose azithromycin in treatment of acute otitis media in children after a baseline tympanocentesis.
作者信息
Dunne Michael W, Khurana Chandra, Mohs Adriano Arguedas, Rodriguez Adib, Arrieta Antonio, McLinn Samuel, Krogstad Judy A, Blatter Mark, Schwartz Richard, Vargas Sergio L, Emparanza Paz, Fernandez Pilar, Gooch Willis M, Aspin Mary, Podgore John, Roine Irmeli, Blumer Jeffrey L, Ehrlich Garth D, Chow Jean
机构信息
Pfizer Global Research & Development, New London, Connecticut 06320, USA.
出版信息
Antimicrob Agents Chemother. 2003 Aug;47(8):2663-5. doi: 10.1128/AAC.47.8.2663-2665.2003.
Abstract
Children with acute otitis media underwent tympanocentesis and were given a single dose of 30 mg of azithromycin/kg of body weight. At day 28, the overall clinical cure rate was 206 of 242 (85%). Clinical cure rates for patients infected with Streptococcus pneumoniae (67 of 76; 88%) and Haemophilus influenzae (28 of 44; 64%) were consistent with historical rates for the 5-day dosing regimen.
摘要
患有急性中耳炎的儿童接受了鼓膜穿刺术，并给予单剂量30毫克/千克体重的阿奇霉素。在第28天，242名患者中有206名（85%）实现了总体临床治愈率。感染肺炎链球菌的患者（76名中的67名；88%）和流感嗜血杆菌的患者（44名中的28名；64%）的临床治愈率与5天给药方案的历史治愈率一致。
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2
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3
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Antimicrob Agents Chemother. 2000 Aug;44(8):2118-25. doi: 10.1128/AAC.44.8.2118-2125.2000.
4
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Antimicrob Agents Chemother. 1999 Jan;43(1):16-20. doi: 10.1128/AAC.43.1.16.
5
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