Picard J, Mills A, Greenwood B
London School of Hygiene and Tropical Medicine, UK.
Trans R Soc Trop Med Hyg. 1992 Nov-Dec;86(6):580-1. doi: 10.1016/0035-9203(92)90135-y.
In recent trials in The Gambia, mass chemoprophylaxis with Maloprim administered over several years by primary health care workers to children aged 3-59 months has reduced both mortality and morbidity without inducing impairment of natural immunity or significant development of drug resistance. Taking expenditure of both time and money, by both public authorities and village volunteers, into account, the costs and the cost effectiveness of such mass chemoprophylaxis are estimated here. The cost per child protected per season was (1990 US) $2.84; the cost per childhood death averted was $143. Both costs compare favourably with those of permethrin bed net impregnation. So in some circumstances where malaria is holoendemic, control of childhood malaria by chemoprophylaxis may be more economically efficient than provision of impregnated bed nets.
在冈比亚最近的试验中，初级卫生保健工作者在数年时间里对3至59个月大的儿童进行了用疟涤平的群体化学预防，这既降低了死亡率，也降低了发病率，同时没有导致自然免疫力受损或耐药性的显著发展。考虑到公共当局和乡村志愿者在时间和金钱方面的投入，在此对这种群体化学预防的成本和成本效益进行了估算。每个受保护儿童每季节的成本为（1990年美元）2.84美元；避免每例儿童死亡的成本为143美元。这两项成本与使用氯菊酯浸蚊帐的成本相比都更有利。因此，在疟疾高度流行的某些情况下，通过化学预防来控制儿童疟疾在经济上可能比提供浸蚊帐更有效。
