Ernest D, French C
Intensive Care Units, Box Hill Hospital and Western Hospital, Melbourne, Victoria.
Anaesth Intensive Care. 2003 Jun;31(3):316-9.
This report describes a fatal case of the propofol infusion syndrome in an adult patient being sedated for a closed head injury using high doses of propofol. The features of circulatory collapse, metabolic acidosis, mild rhabdomyolysis and renal impairment are consistent with the syndrome and not readily attributable to alternative aetiologies. Potential mechanisms for the syndrome may relate to antagonism of beta-receptors, impaired myocardial oxygen utilization and a specific disruption to fatty-acid oxidation. This is the first published Australian case of the propofol infusion syndrome in an adult and should serve as an additional case report to the existing literature highlighting this potentially fatal syndrome in adults.
本报告描述了一例成年患者因闭合性颅脑损伤接受大剂量丙泊酚镇静时发生丙泊酚输注综合征致死的病例。循环衰竭、代谢性酸中毒、轻度横纹肌溶解和肾功能损害等特征与该综合征相符，且不太可能归因于其他病因。该综合征的潜在机制可能与β受体拮抗、心肌氧利用受损以及脂肪酸氧化的特定破坏有关。这是澳大利亚首次发表的成年患者丙泊酚输注综合征病例报告，应作为现有文献的补充病例报告，突出这种在成年人中潜在致命的综合征。
