Ming Zhijun, Davis Cheryl D
Department of Pharmacy, School of Medicine, Soochow University, Sozhou 215007, People's Republic of China.
J Parasitol. 2003 Jun;89(3):630-2. doi: 10.1645/0022-3395(2003)089[0630:CTLRFE]2.0.CO;2.
C3H mice, which are highly susceptible to infection with the Brazil strain of Trypanosoma cruzi, not only survive infection when maintained at elevated environmental temperature, but also experience reduced parasitemias, reduced tissue pathology, and enhanced immune responsiveness. The contribution of CD8+ T cells to this phenomenon was investigated using the in vivo cell-depletion technique. The depletion of CD8+ T lymphocytes with purified monoclonal antibody resulted in an abrogation of the protective effects of elevated environmental temperature during T. cruzi infection, as evidenced by high parasitemia levels and 100% mortality in monoclonal antibody-treated mice.
C3H小鼠对克氏锥虫巴西株感染高度敏感，当饲养在较高环境温度下时，它们不仅能在感染中存活，而且寄生虫血症降低、组织病理学变化减轻，免疫反应性增强。使用体内细胞清除技术研究了CD8 + T细胞对这一现象的作用。用纯化的单克隆抗体清除CD8 + T淋巴细胞导致在克氏锥虫感染期间较高环境温度的保护作用消失，这在单克隆抗体处理的小鼠中表现为高寄生虫血症水平和100%的死亡率。
