一种来自玫瑰果（犬蔷薇）的具有抗炎作用的半乳糖脂，其在体外可抑制人外周血中性粒细胞的趋化性。
An antiinflammatory galactolipid from rose hip (Rosa canina) that inhibits chemotaxis of human peripheral blood neutrophils in vitro.
作者信息
Larsen Erik, Kharazmi Arsalan, Christensen Lars P, Christensen S Brøgger
机构信息
Department of Food Science, Danish Institute of Agricultural Sciences, Research Centre Aarslev, Kirstinebjergvej 10, DK-5792 Aarslev, Denmark.
出版信息
J Nat Prod. 2003 Jul;66(7):994-5. doi: 10.1021/np0300636.
The galactolipid (2S)-1,2-di-O-[(9Z,12Z,15Z)-octadeca-9,12,15-trienoyl]-3-O-beta-d-galactopyranosyl glycerol (1) isolated from dried and milled fruits of Rosa canina by bioassay-guided fractionation is an antiinflammatory agent with inhibitory effects on chemotaxis of human peripheral blood neutrophils in vitro. The inhibition of cell migration is not related to toxicity. The presence of 1 in rose hips may explain the clinically observed antiinflammatory properties of rose hip herbal remedies.
通过生物活性导向分离从犬蔷薇干燥研磨果实中分离得到的半乳糖脂（2S）-1,2-二-O-[(9Z,12Z,15Z)-十八碳-9,12,15-三烯酰基]-3-O-β-D-吡喃半乳糖基甘油（1）是一种抗炎剂，在体外对人外周血中性粒细胞的趋化性具有抑制作用。细胞迁移的抑制与毒性无关。玫瑰果中1的存在可能解释了玫瑰果草药疗法临床上观察到的抗炎特性。
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