Fulda Simone, Debatin Klaus Michael
University Children's Hospital, Prittwitzstr. 43, D-89075 Ulm, Germany.
Cancer Lett. 2003 Jul 18;197(1-2):131-5. doi: 10.1016/s0304-3835(03)00091-0.
Apoptosis, the cell's intrinsic death program, plays a crucial role in the regulation of tissue homeostasis, and an imbalance between cell death and proliferation may result in tumor formation. Also, killing of tumor cells by diverse cytotoxic approaches such as anticancer drugs, gamma-irradiation, suicide genes or immunotherapy, is predominantly mediated through induction of apoptosis. Failure to activate apoptotic pathways in response to drug treatment may lead to resistance of neuroblastoma cells to anticancer therapies. Understanding the molecular events that regulate apoptosis induced by cytotoxic therapies and how neuroblastoma cells evade apoptotic events may provide a new paradigm for neuroblastoma therapy. Thus, novel strategies targeting resistance of neuroblastoma cells will be based on insights into the molecular mechanisms of apoptosis as well as other forms of cell death.
细胞凋亡，即细胞的内在死亡程序，在组织稳态调节中起着关键作用，细胞死亡与增殖之间的失衡可能导致肿瘤形成。此外，通过多种细胞毒性方法（如抗癌药物、γ射线照射、自杀基因或免疫疗法）杀死肿瘤细胞，主要是通过诱导细胞凋亡来介导的。对药物治疗无反应而未能激活凋亡途径可能导致神经母细胞瘤细胞对抗癌治疗产生耐药性。了解调节细胞毒性疗法诱导的细胞凋亡的分子事件以及神经母细胞瘤细胞如何逃避凋亡事件，可能为神经母细胞瘤治疗提供新的范例。因此，针对神经母细胞瘤细胞耐药性的新策略将基于对细胞凋亡以及其他形式细胞死亡的分子机制的深入了解。
