Suarez Edward C
Department of Psychiatry and Behavioral Science, Duke University Medical Center, Durham, North Carolina 27710, USA.
Psychosom Med. 2003 Jul-Aug;65(4):523-7. doi: 10.1097/01.psy.0000062530.94551.ea.
Although interleukin (IL)-6 plays a significant role in cardiovascular disease, little is known about its relation to psychological risk factors, such as hostility and severity of depressive symptoms. The current study examined the joint effects of severity of depressive symptoms and hostility on plasma IL-6 in a sample of 90 healthy, nonsmoking men.
After an overnight fast, blood samples for plasma IL-6 and fasting lipids were collected on the same day that the Beck Depression Inventory (BDI) and the Cook-Medley hostility (Ho) scale were administered. Plasma IL-6 was determined using enzymatic-linked immunosorbent assay (ELISA).
Analyses of logarithmically normalized plasma IL-6 adjusting for age, body mass index (BMI), fasting total cholesterol, high density lipoprotein (HDL), and resting diastolic blood pressure (DBP) revealed a significant BDI by Ho interaction (p =.026). Post hoc decomposition revealed that Ho was correlated with log-normalized plasma IL-6 (r = 0.59, p =.025) but only among men with BDI scores of 10 and above. Alternatively, BDI was correlated with log-normalized plasma IL-6 (r = 0.61, p =.003) but only among men with Ho scores of 23 and higher. Comparisons among BDI/Ho groups indicated that men with high scores on both the BDI and the Ho exhibited the highest median levels of plasma IL-6.
Hostile men who exhibited above normal levels of depressive symptoms had higher plasma levels of IL-6 suggestive of a subpopulation at increased risk for future cardiac events.
尽管白细胞介素（IL）-6在心血管疾病中发挥着重要作用，但其与心理风险因素（如敌意和抑郁症状严重程度）之间的关系却鲜为人知。本研究在90名健康、不吸烟男性样本中，考察了抑郁症状严重程度和敌意对血浆IL-6的联合影响。
在禁食过夜后，于同一天采集血浆IL-6和空腹血脂的血样，同时进行贝克抑郁量表（BDI）和库克-梅德利敌意（Ho）量表测试。采用酶联免疫吸附测定法（ELISA）测定血浆IL-6。
对经年龄、体重指数（BMI）、空腹总胆固醇、高密度脂蛋白（HDL）和静息舒张压（DBP）校正的对数标准化血浆IL-6进行分析，结果显示BDI与Ho存在显著交互作用（p = 0.026）。事后分解表明，Ho与对数标准化血浆IL-6相关（r = 0.59，p = 0.025），但仅在BDI得分10及以上的男性中如此。或者说，BDI与对数标准化血浆IL-6相关（r = 0.61，p = 0.003），但仅在Ho得分23及以上的男性中如此。BDI/Ho组之间的比较表明，BDI和Ho得分均高的男性血浆IL-6中位数水平最高。
表现出高于正常水平抑郁症状的敌意男性，其血浆IL-6水平较高，这表明该亚组人群未来发生心脏事件的风险增加。
