Wang Tungte, Schultz Georg, Hebestreit Helge, Hebestreit Alexandra, Hahn Dietbert, Jakob Peter M
Department of Physics, University of Würzburg, Würzburg, Germany.
J Magn Reson Imaging. 2003 Aug;18(2):260-5. doi: 10.1002/jmri.10338.
To evaluate the feasibility and reproducibility of a noninvasive, rapid and quantitative pulmonary perfusion mapping method using a two-compartment tissue model in combination with a (1)H spin labeling technique.
Ten healthy volunteers and three patients with cystic fibrosis (CF) were examined on a 1.5-T whole-body scanner. Global and selective lung T(1) maps based on an inversion recovery Snapshot FLASH technique were acquired from each subject with breath-holds at end-expiration. For comparison, corresponding Gd-DTPA-enhanced (1)H MR perfusion images were also obtained from each CF patient.
Quantitative perfusion maps were calculated from the global and selective T(1) maps. The measured perfusion rates of the upper right lung in volunteers ranged from 400 to 600 mL/100 g/minute. The method showed a high intra-study reproducibility and low relative errors. In CF-patients, perfusion defects detected using Gd-DTPA-enhanced MR imaging were also detected using the spin labeling method. The perfusion rates of diseased lung tissues were less than 200 mL/100 g/minute.
Noninvasive, robust and quantitative (1)H MR mapping of pulmonary perfusion was successfully performed using a rapid lung T(1) mapping in combination with spin labeling within the imaging slice. The proposed method has the potential to provide both important qualitative functional information and quantitative pulmonary perfusion rates in various lung diseases at various stages without the need of contrast agents.
评估一种使用双室组织模型结合(1)H自旋标记技术的无创、快速且定量的肺灌注成像方法的可行性和可重复性。
对10名健康志愿者和3名囊性纤维化(CF)患者在1.5-T全身扫描仪上进行检查。基于反转恢复快速成像序列(Snapshot FLASH)技术获取每个受试者在呼气末屏气时的全肺和选择性肺T(1)图谱。作为对照,也从每位CF患者获取相应的钆喷酸葡胺(Gd-DTPA)增强(1)H磁共振灌注图像。
从全肺和选择性T(1)图谱计算出定量灌注图。志愿者右上肺的测量灌注率范围为400至600 mL/100 g/分钟。该方法显示出较高的研究内可重复性和较低的相对误差。在CF患者中,使用自旋标记法也检测到了用Gd-DTPA增强磁共振成像检测到的灌注缺损。病变肺组织的灌注率小于200 mL/100 g/分钟。
通过快速肺T(1)图谱结合成像层面内的自旋标记成功实现了无创、稳健且定量的(1)H磁共振肺灌注成像。所提出的方法有可能在无需使用对比剂的情况下,为各阶段的各种肺部疾病提供重要的定性功能信息和定量肺灌注率。