Schraml Christina, Boss Andreas, Martirosian Petros, Schwenzer Nina F, Claussen Claus D, Schick Fritz
Section on Experimental Radiology, Eberhard Karls University, Tuebingen, Germany.
J Magn Reson Imaging. 2007 Jul;26(1):66-71. doi: 10.1002/jmri.20943.
To evaluate the feasibility of quantitative perfusion MRI of the thyroid gland using an arterial spin labeling (ASL) method.
An ASL technique with flow-sensitive alternating inversion-recovery (FAIR) spin preparation and a true fast imaging in the steady state (TrueFISP) signal readout strategy was implemented on a 1.5T whole-body unit. Anatomical and perfusion imaging of the thyroid gland was performed in eight healthy volunteers and one patient with functioning adenoma. Quantitative perfusion maps were calculated using the extended Bloch equations.
In all subjects the perfusion images showed diagnostic image quality. The mean examination time was 24 minutes for multiplanar perfusion imaging of the entire thyroid gland. Individual perfusion values ranged between 341 +/- 91 and 640 +/- 90 mL/100 g/minute, with a mean perfusion of 461 +/- 90 mL/100 g/minute. The functioning adenoma showed markedly reduced perfusion compared to normal thyroidal parenchyma. No perfusion was noticeable inside four detected thyroid cysts.
Quantitative ASL perfusion imaging of the thyroid gland using a FAIR-TrueFISP sequence leads to perfusion maps that may provide important information for assessing thyroid gland pathologies and monitoring therapeutic treatment.
评估采用动脉自旋标记（ASL）方法对甲状腺进行定量灌注磁共振成像的可行性。
在一台1.5T全身磁共振成像设备上实施了具有流动敏感交替反转恢复（FAIR）自旋准备和稳态真快速成像（TrueFISP）信号读出策略的ASL技术。对8名健康志愿者和1名患有功能性腺瘤的患者进行了甲状腺的解剖和灌注成像。使用扩展的布洛赫方程计算定量灌注图。
在所有受试者中，灌注图像均显示出具有诊断价值的图像质量。对整个甲状腺进行多平面灌注成像的平均检查时间为24分钟。个体灌注值在341±91至640±90毫升/100克/分钟之间，平均灌注为461±90毫升/100克/分钟。与正常甲状腺实质相比，功能性腺瘤的灌注明显降低。在4个检测到的甲状腺囊肿内未观察到灌注。
使用FAIR-TrueFISP序列对甲状腺进行定量ASL灌注成像可生成灌注图，这些灌注图可能为评估甲状腺疾病和监测治疗提供重要信息。
