Fedorova L M, Arkhangel'skaia S L, Bilenko M V
Biull Eksp Biol Med. 1992 Oct;114(10):405-6.
The experiments were performed on 126 white male rats. The inclusion of 3H-thymidine in nuclear DNA of the liver was studied on h 24 and 48 after 70% resection of the liver versus prodigiosan injection or combination of prodigiosan with 70% resection of the liver. Liver extracts stimulating proliferation (ESP) obtained under the above schedules were studied on the model of 30% liver resection. It is shown that prodigiosan (0.25 mg/kg) injected to intact rats and rats with 70% resected liver initiated ESP production promoting the inclusion of 3H-thymidine in nuclear DNA of the liver after 30% resection of the liver.
实验在126只白色雄性大鼠身上进行。研究了在肝脏70%切除术后24小时和48小时，与注射灵菌红素或灵菌红素与肝脏70%切除联合处理相比，肝脏核DNA中3H-胸腺嘧啶核苷的掺入情况。在30%肝切除模型上研究了按上述方案获得的刺激增殖的肝脏提取物（ESP）。结果表明，向完整大鼠和肝脏70%切除的大鼠注射灵菌红素（0.25mg/kg）可引发ESP产生，促进在30%肝切除后肝脏核DNA中3H-胸腺嘧啶核苷的掺入。
