英夫利昔单抗和甲氨蝶呤成功治疗与克罗恩病相关的增殖性口炎

Successful treatment with infliximab and methotrexate of pyostomatitis vegetans associated with Crohn's disease.

作者信息

Bens G, Laharie D, Beylot-Barry M, Vergier B, Noblesse I, Beylot C, Amouretti M

机构信息

Departments of Dermatology, Hôpital du Haut-Lévêque, Bordeaux University Hospital, Avenue de Magellan, F-33604 Pessac cedex, Bordeaux, France.

出版信息

Br J Dermatol. 2003 Jul;149(1):181-4. doi: 10.1046/j.1365-2133.2003.05385.x.

DOI:10.1046/j.1365-2133.2003.05385.x

PMID:12890215

Abstract

A 35-year-old woman with severe fistulizing Crohn's disease presented with pyostomatitis vegetans affecting both the mouth and the vulva. The coalescing pustules transformed within several days into vegetating lesions on areas of inflammation. Microbial assessments revealed no pathogenic agent. Histology showed neutrophilic microabscesses, but no granulomas. Three injections of infliximab and maintenance therapy with methotrexate resulted in rapid and complete regression of both the pyostomatitis vegetans and the Crohn's disease. Infliximab and methotrexate may be a promising treatment for the rare cases of pyostomatitis vegetans associated with Crohn's disease.

摘要

一名患有严重瘘管性克罗恩病的35岁女性出现了增殖性脓口炎，累及口腔和外阴。融合性脓疱在数天内转变为炎症部位的增殖性病变。微生物评估未发现病原体。组织学显示中性粒细胞微脓肿，但无肉芽肿。三次注射英夫利昔单抗并联合甲氨蝶呤维持治疗，使增殖性脓口炎和克罗恩病迅速完全消退。英夫利昔单抗和甲氨蝶呤可能是治疗与克罗恩病相关的罕见增殖性脓口炎病例的一种有前景的疗法。