优特克单抗成功治疗并维持克罗恩病相关的增殖性口炎缓解状态。
Ustekinumab Successfully Treats and Maintains Remission of Pyostomatitis Vegetans Associated with Crohn's Disease.
作者信息
Abi Doumeth Sarah, Abbas Ossama, Hashash Jana G
机构信息
Division of Gastroenterology and Hepatology, American University of Beirut, Beirut, Lebanon.
Department of Internal Medicine, American University of Beirut, Beirut, Lebanon.
出版信息
Crohns Colitis 360. 2020 Mar 13;2(1):otaa014. doi: 10.1093/crocol/otaa014. eCollection 2020 Jan.
Pyostomatitis vegetans (PV) is a rare inflammatory stomatitis often associated with inflammatory bowel diseases (IBD). Treatment of PV depends on the presence of coexisting IBD. To date, there have been no reports on the use of ustekinumab for PV. There have been recent cases on the use of ustekinumab for treatment of pyoderma gangrenosum and uveitis. We report the case of a 26-year-old female with moderately severe Crohn's disease (CD) and PV who was successfully treated with ustekinumab monotherapy. Since initiation of ustekinumab, she has been in clinical and biochemical remission from a CD and PV standpoint for the last 12 months.
增殖性脓口炎（PV）是一种罕见的炎症性口腔炎，常与炎症性肠病（IBD）相关。PV的治疗取决于是否存在并存的IBD。迄今为止，尚无关于使用乌司奴单抗治疗PV的报道。最近有使用乌司奴单抗治疗坏疽性脓皮病和葡萄膜炎的病例。我们报告一例26岁患有中度重度克罗恩病（CD）和PV的女性患者，其接受乌司奴单抗单药治疗获得成功。自开始使用乌司奴单抗以来，从CD和PV的角度来看，她在过去12个月中一直处于临床和生化缓解状态。
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