Nagler R M, Salameh F, Reznick A Z, Livshits V, Nahir A M
Department of Oral and Maxillofacial Surgery, Rambam Medical Center and the Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa.
Rheumatology (Oxford). 2003 Oct;42(10):1234-41. doi: 10.1093/rheumatology/keg362. Epub 2003 Jul 30.
The objective of the present study was to analyse salivary gland and free radical involvement in rheumatoid arthritis (RA).
Thirty-four consenting RA patients (rheumatoid factor-positive) and 18 healthy controls, matched in age and gender, participated in the study. Plasma and saliva samples were harvested and subjected to compositional analysis and various free radical-related tests.
The mean salivary flow rate was lower in the RA patients than in the control group, whereas all plasma and salivary antioxidants were increased. Mean values of plasma malondialdehyde and ceruloplasmin were higher in the RA patients.
The effects of RA on salivary gland flow rates and antioxidant compositional parameters may be of great importance for the further elucidation of the role of free radicals in RA pathogenesis and for its general diagnosis and evaluation. The demonstrated correlation between the altered salivary parameters and the severity of the disease may indicate that evaluation of the salivary status of RA patients is warranted.
本研究的目的是分析唾液腺和自由基在类风湿关节炎（RA）中的作用。
34名同意参与研究的类风湿因子阳性的RA患者和18名年龄及性别匹配的健康对照者参与了本研究。采集血浆和唾液样本并进行成分分析以及各种与自由基相关的检测。
RA患者的平均唾液流速低于对照组，而所有血浆和唾液抗氧化剂均增加。RA患者血浆丙二醛和铜蓝蛋白的平均值更高。
RA对唾液腺流速和抗氧化剂成分参数的影响对于进一步阐明自由基在RA发病机制中的作用及其总体诊断和评估可能非常重要。唾液参数改变与疾病严重程度之间已证实的相关性可能表明有必要评估RA患者的唾液状态。
