Speechley J A, Rugman F P
Warrington Health Authority, UK.
Dent Update. 1992 Jun;19(5):204-6.
Anticoagulants have been used to reduce the risk of embolic and thrombotic complications in patients at risk since the discovery of the coumarin drug warfarin sodium in 1941. Since then, both the spectrum of disease for which anticoagulation is recommended and the range of anticoagulants has widened. In addition to treatment with conventional anticoagulant drugs, many patients nowadays have an additional bleeding defect due to the therapeutic use of daily low-dose aspirin therapy, either alone or in combination with other drugs. The aim of this report is to highlight some of the important aspects of anticoagulant therapy and its relevance to dental treatment.
自1941年发现香豆素类药物华法林钠以来，抗凝剂一直被用于降低有风险患者发生栓塞和血栓形成并发症的风险。从那时起，推荐进行抗凝治疗的疾病谱以及抗凝剂的范围都有所扩大。除了使用传统抗凝药物治疗外，如今许多患者由于每日使用低剂量阿司匹林治疗（单独使用或与其他药物联合使用）进行治疗而存在额外的出血缺陷。本报告的目的是强调抗凝治疗的一些重要方面及其与牙科治疗的相关性。
