在rpsD中携带核糖体模糊突变的大肠杆菌细胞具有与错译增加相关的突变表型。
Escherichia coli cells bearing a ribosomal ambiguity mutation in rpsD have a mutator phenotype that correlates with increased mistranslation.
作者信息
Balashov Sergey, Humayun M Zafri
机构信息
University of Medicine and Dentistry of New Jersey--New Jersey Medical School, Department of Microbiology and Molecular Genetics, International Center for Public Health, Newark, New Jersey 07101-1709, USA.
出版信息
J Bacteriol. 2003 Aug;185(16):5015-8. doi: 10.1128/JB.185.16.5015-5018.2003.
Abstract
Escherichia coli cells bearing certain mutations in rpsD (coding for the 30S ribosomal protein S4) show a ribosomal ambiguity (Ram) phenotype characterized by increased translational error rates. Here we show that spontaneous mutagenesis increases in Ram cells bearing the rpsD14 allele, suggesting that the recently described translational stress-induced mutagenesis pathway is activated in Ram cells.
摘要
在rpsD（编码30S核糖体蛋白S4）中携带某些突变的大肠杆菌细胞表现出核糖体模糊性（Ram）表型，其特征是翻译错误率增加。在这里，我们表明，携带rpsD14等位基因的Ram细胞中自发诱变增加，这表明最近描述的翻译应激诱导诱变途径在Ram细胞中被激活。
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1
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J Biol Chem. 2002 Nov 29;277(48):46319-27. doi: 10.1074/jbc.M206856200. Epub 2002 Sep 24.
2
Expression of mutant alanine tRNAs increases spontaneous mutagenesis in Escherichia coli.
Mol Microbiol. 2002 Apr;44(1):131-41. doi: 10.1046/j.1365-2958.2002.02847.x.
3
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4
Ribosomal protein S4 is a transcription factor with properties remarkably similar to NusA, a protein involved in both non-ribosomal and ribosomal RNA antitermination.
EMBO J. 2001 Jul 16;20(14):3811-20. doi: 10.1093/emboj/20.14.3811.
5
The miaA mutator phenotype of Escherichia coli K-12 requires recombination functions.
J Bacteriol. 2001 Mar;183(5):1796-800. doi: 10.1128/JB.183.5.1796-1800.2001.
6
The Escherichia coli UVM response is accompanied by an SOS-independent error-prone DNA replication activity demonstrable in vitro.
Mol Microbiol. 2000 Oct;38(2):368-80. doi: 10.1046/j.1365-2958.2000.02136.x.
7
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Biochimie. 2000 Aug;82(8):683-91. doi: 10.1016/s0300-9084(00)01160-3.
8
Requirement for homologous recombination functions for expression of the mutA mistranslator tRNA-induced mutator phenotype in Escherichia coli.
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9
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