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本文引用的文献

1
The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis.内源性大麻素系统通过中枢促食欲驱动力和外周脂肪生成来影响能量平衡。
J Clin Invest. 2003 Aug;112(3):423-31. doi: 10.1172/JCI17725.
2
Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults.美国成年人前瞻性队列研究中的超重、肥胖与癌症死亡率
N Engl J Med. 2003 Apr 24;348(17):1625-38. doi: 10.1056/NEJMoa021423.
3
The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis.胃饥饿素在中枢神经系统中的分布及作用机制表明存在一条调节能量平衡的新型下丘脑回路。
Neuron. 2003 Feb 20;37(4):649-61. doi: 10.1016/s0896-6273(03)00063-1.
4
Y2 receptor deletion attenuates the type 2 diabetic syndrome of ob/ob mice.Y2受体缺失减轻了ob/ob小鼠的2型糖尿病综合征。
Diabetes. 2002 Dec;51(12):3420-7. doi: 10.2337/diabetes.51.12.3420.
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Prevalence and trends in obesity among US adults, 1999-2000.1999 - 2000年美国成年人肥胖症的患病率及趋势
JAMA. 2002 Oct 9;288(14):1723-7. doi: 10.1001/jama.288.14.1723.
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Genetic approaches to studying energy balance: perception and integration.研究能量平衡的遗传学方法：感知与整合
Nat Rev Genet. 2002 Aug;3(8):589-600. doi: 10.1038/nrg862.
7
Neither agouti-related protein nor neuropeptide Y is critically required for the regulation of energy homeostasis in mice.刺鼠相关蛋白和神经肽Y对小鼠能量平衡的调节都不是至关重要的。
Mol Cell Biol. 2002 Jul;22(14):5027-35. doi: 10.1128/MCB.22.14.5027-5035.2002.
8
Endocannabinoid structure-activity relationships for interaction at the cannabinoid receptors.内源性大麻素与大麻素受体相互作用的构效关系。
Prostaglandins Leukot Essent Fatty Acids. 2002 Feb-Mar;66(2-3):143-60. doi: 10.1054/plef.2001.0343.
9
The feeding response to melanin-concentrating hormone is attenuated by antagonism of the NPY Y(1)-receptor in the rat.在大鼠中，通过拮抗神经肽Y Y(1)受体可减弱对促黑素细胞激素的摄食反应。
Endocrinology. 2002 Jan;143(1):191-7. doi: 10.1210/endo.143.1.8569.
10
Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus.瘦素通过弓状核中的神经网络激活厌食性促黑素细胞激素（POMC）神经元。
Nature. 2001 May 24;411(6836):480-4. doi: 10.1038/35078085.

内源性大麻素与体脂调节：迷雾渐散。

Endocannabinoids and the regulation of body fat: the smoke is clearing.

作者信息

Horvath Tamas L

机构信息

Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520, USA.

出版信息

J Clin Invest. 2003 Aug;112(3):323-6. doi: 10.1172/JCI19376.

DOI:10.1172/JCI19376
PMID:12897199
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC166302/
Abstract

Endocannabinoids, endogenous ligands of cannabinoid receptor type 1 (CB1), have emerged as novel and important regulators of energy homeostasis. A report in this issue demonstrates reduced body weight, fat mass, and appetite in CB1-/- mice. Examination of the underlying mechanisms reveals a dual role for endocannabinoids as they affect both appetite and peripheral lipolysis.

摘要

内源性大麻素是1型大麻素受体（CB1）的内源性配体，已成为能量平衡的新型重要调节因子。本期的一篇报道显示，CB1基因敲除小鼠的体重、脂肪量和食欲均有所降低。对潜在机制的研究揭示了内源性大麻素的双重作用，因为它们既影响食欲，也影响外周脂肪分解。