内源性大麻素与体脂调节：迷雾渐散。
Endocannabinoids and the regulation of body fat: the smoke is clearing.
作者信息
Horvath Tamas L
机构信息
Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520, USA.
出版信息
J Clin Invest. 2003 Aug;112(3):323-6. doi: 10.1172/JCI19376.
Abstract
Endocannabinoids, endogenous ligands of cannabinoid receptor type 1 (CB1), have emerged as novel and important regulators of energy homeostasis. A report in this issue demonstrates reduced body weight, fat mass, and appetite in CB1-/- mice. Examination of the underlying mechanisms reveals a dual role for endocannabinoids as they affect both appetite and peripheral lipolysis.
摘要
内源性大麻素是1型大麻素受体（CB1）的内源性配体，已成为能量平衡的新型重要调节因子。本期的一篇报道显示，CB1基因敲除小鼠的体重、脂肪量和食欲均有所降低。对潜在机制的研究揭示了内源性大麻素的双重作用，因为它们既影响食欲，也影响外周脂肪分解。
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本文引用的文献
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J Clin Invest. 2003 Aug;112(3):423-31. doi: 10.1172/JCI17725.
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Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults.美国成年人前瞻性队列研究中的超重、肥胖与癌症死亡率
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The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis.胃饥饿素在中枢神经系统中的分布及作用机制表明存在一条调节能量平衡的新型下丘脑回路。
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