Shafiee M A S, Bohn D, Hoorn E J, Halperin M L
Renal Division, St. Michael's Hospital, University of Toronto, Toronto, Canada.
QJM. 2003 Aug;96(8):601-10. doi: 10.1093/qjmed/hcg101.
Hyponatraemia is the commonest electrolyte abnormality in hospitalized patients. If the plasma sodium concentration (P(Na)) declines to approximately 120 mM in <48 h, brain cell swelling might result in herniation, with devastating consequences. The volume and/or the composition of fluids used for intravenous therapy often contribute to the development of acute hyponatraemia. Our hypothesis is that the traditional calculation of the daily loss of insensible water overestimates this parameter, leading to an excessive daily recommended requirement for water. We offer suggestions to minimize the risk of iatrogenic hyponatraemia.
低钠血症是住院患者中最常见的电解质异常。如果血浆钠浓度（P(Na)）在<48小时内降至约120 mM，脑细胞肿胀可能导致脑疝，后果严重。静脉治疗所用液体的量和/或成分常常促使急性低钠血症的发生。我们的假设是，传统计算的每日不显性失水量高估了该参数，导致每日推荐的水需求量过多。我们提出建议以尽量降低医源性低钠血症的风险。
