Kapetansky Frederick M
Ohio State University, Columbus, OH 43215, USA.
J Glaucoma. 2003 Aug;12(4):316-20. doi: 10.1097/00061198-200308000-00005.
The author attempted to avoid ocular hypotony following a mitomycin-C trabeculectomy by controlling the interval between surgery and laser suture lysis.
When 10 seconds of digital pressure on the eye following a mitomycin-C trabeculectomy produced a 20% drop of the intraocular pressure, the decision of whether or not to perform laser suture lysis was delayed until the following examination.
Twenty-nine consecutive eyes (27 patients) with primary open-angle glaucoma underwent mitomycin-C trabeculectomy in which laser suture lysis was required during the postoperative period to reach the target intraocular pressure. The eyes were classified by the severity of the glaucoma: mild, moderate, and severe. For moderate and severe glaucoma, an unqualified success was defined as an intraocular pressure of 10 +/- 2 mm Hg. A qualified success had an intraocular pressure of 5 to 7 mm Hg or 13 to 15 mm Hg. Failure was defined as an intraocular pressure less than 5 mm Hg or greater than 15 mm Hg. Fifteen eyes were called success, 7 eyes qualified success, and 7 eyes failure. When the final laser suture lysis was carried out within the first two postoperative months, two of the failure eyes sustained hypotony. If the final laser suture lysis had been carried out after the first two postoperative months, there were no eyes with hypotony. There was no statistical difference in the final intraocular pressure between the early laser suture lysis and late laser suture lysis groups.
From this pilot study it would appear that delaying the final laser suture lysis following trabeculectomy (MMC) until after the second postoperative month may reduce the risk of hypotony without adversely affecting the final intraocular pressure.
作者试图通过控制丝裂霉素C小梁切除术后手术与激光缝线松解之间的间隔时间来避免眼压过低。
在丝裂霉素C小梁切除术后,当用手指按压眼球10秒导致眼压下降20%时,决定是否进行激光缝线松解的时间推迟至下次检查。
连续29只眼(27例患者)患有原发性开角型青光眼,接受了丝裂霉素C小梁切除术,术后需要进行激光缝线松解以达到目标眼压。根据青光眼的严重程度将这些眼分为轻度、中度和重度。对于中度和重度青光眼,将眼压为10±2mmHg定义为完全成功。合格成功的眼压为5至7mmHg或13至15mmHg。失败定义为眼压低于5mmHg或高于15mmHg。15只眼为成功,7只眼为合格成功,7只眼为失败。当在术后的前两个月内进行最终的激光缝线松解时,有2只失败的眼出现了眼压过低。如果在术后的前两个月之后进行最终的激光缝线松解,则没有眼出现眼压过低。早期激光缝线松解组和晚期激光缝线松解组的最终眼压没有统计学差异。
从这项初步研究来看,小梁切除术(丝裂霉素C)后将最终的激光缝线松解推迟至术后第二个月之后,可能会降低眼压过低的风险,而不会对最终眼压产生不利影响。