Hirooka Kazuyuki, Shiraga Fumio
Department of Ophthalmology, Kagawa Medical University, Miki, Kagawa, Japan.
J Glaucoma. 2003 Aug;12(4):379-82. doi: 10.1097/00061198-200308000-00015.
To determine the relationship between the postural changes of the intraocular pressure and the visual field loss in patients with primary open-angle glaucoma.
Eleven normal subjects and 11 patients with primary open-angle glaucoma were studied. Intraocular pressure was measured in both the sitting and the supine positions. Visual fields were measured with automated perimetry.
When patients moved from a sitting to supine position, the intraocular pressure increased by an average of 3.1 +/- 0.4 mm Hg (mean +/- SEM) in normal subjects and 4.0 +/- 0.2 mm Hg in patients with primary open-angle glaucoma. There was a significant difference between the normal subjects and patients with primary open-angle glaucoma (P = 0.049). Intraocular pressure increased by 4.4 +/- 0.3 mm Hg (P = 0.02) in the worse eye for mean deviation and 3.6 +/- 0.3 mm Hg (P = 0.38) in the better eye for mean deviation. There was no significant difference in intraocular pressure in the sitting position between both groups.
The greatest difference in intraocular pressure between the sitting and supine positions was observed in the worse eye of patients with primary open-angle glaucoma. This result suggests that damage to the optic nerve in primary open-angle glaucoma might occur when patients are asleep in the supine position.
确定原发性开角型青光眼患者眼压的体位变化与视野缺损之间的关系。
对11名正常受试者和11名原发性开角型青光眼患者进行研究。测量坐位和仰卧位时的眼压。使用自动视野计测量视野。
当患者从坐位变为仰卧位时，正常受试者的眼压平均升高3.1±0.4 mmHg（平均值±标准误），原发性开角型青光眼患者的眼压平均升高4.0±0.2 mmHg。正常受试者与原发性开角型青光眼患者之间存在显著差异（P = 0.049）。平均偏差较差眼的眼压升高4.4±0.3 mmHg（P = 0.02），平均偏差较好眼的眼压升高3.6±0.3 mmHg（P = 0.38）。两组坐位时的眼压无显著差异。
在原发性开角型青光眼患者的较差眼中，观察到坐位和仰卧位之间眼压的最大差异。这一结果表明，原发性开角型青光眼患者在仰卧位睡眠时可能会发生视神经损伤。
