Perry Tamara, Matsui Elizabeth, Merriman Barry, Duong Trang, Eggleston Peyton
Department of Pediatrics, Division of Allergy and Immunology, Johns Hopkins University, School of Medicine, Baltimore, MD, USA.
J Allergy Clin Immunol. 2003 Aug;112(2):346-52. doi: 10.1067/mai.2003.1640.
Rat allergen has proved to be an important cause of IgE-mediated hypersensitivity in the occupational setting. The prevalence and significance of rat allergen in homes has not been studied.
The purpose of this study was to determine the prevalence of rat allergen in the homes of inner-city children with asthma and to examine the relationship between rat allergen exposure, sensitization, and asthma morbidity.
We developed a new monoclonal-based ELISA to determine the prevalence of rat allergen in dust samples from inner-city homes of the National Cooperative Inner-City Asthma Study population. Home characteristics were evaluated to detect variables that were associated with the presence of rat allergen. Data were also analyzed to assess the relationship between the presence of rat allergen, sensitization, and asthma morbidity.
Thirty-three percent of inner-city homes had detectable rat allergen (Rat n 1). The presence of rat allergen was associated with reported rat and mouse infestation, as well as evidence of mouse infestation on home inspection. Twenty-one percent of the participants were sensitized to rat allergen; however, sensitization was not more common when rat allergen was found in the home. The number of hospitalizations, unscheduled medical visits, and days with slowed activity because of asthma were significantly increased in those individuals who were both sensitized and exposed to rat allergen.
Rat allergen sensitization and exposure are associated with increased asthma morbidity in inner-city children.
在职业环境中，鼠过敏原已被证明是IgE介导的超敏反应的一个重要原因。家庭中鼠过敏原的患病率及意义尚未得到研究。
本研究旨在确定内城区哮喘儿童家庭中鼠过敏原的患病率，并探讨鼠过敏原暴露、致敏与哮喘发病率之间的关系。
我们开发了一种基于单克隆抗体的新型酶联免疫吸附测定法（ELISA），以确定来自国家内城区哮喘合作研究人群的内城区家庭灰尘样本中鼠过敏原的患病率。对家庭特征进行评估，以检测与鼠过敏原存在相关的变量。还对数据进行了分析，以评估鼠过敏原的存在、致敏与哮喘发病率之间的关系。
33%的内城区家庭检测到鼠过敏原（鼠n1）。鼠过敏原的存在与报告的鼠类和鼠类侵扰以及家庭检查中鼠类侵扰的证据有关。21%的参与者对鼠过敏原致敏；然而，在家中发现鼠过敏原时，致敏情况并不更常见。在那些既致敏又接触鼠过敏原的个体中，因哮喘导致的住院次数、非计划就诊次数以及活动减缓天数显著增加。
鼠过敏原致敏和暴露与内城区儿童哮喘发病率增加有关。
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