Phipatanakul W, Eggleston P A, Wright E C, Wood R A
Department of Pediatrics, Division of Allergy and Immunology, Children's Hospital, Harvard University School of Medicine, Boston, MA, USA.
J Allergy Clin Immunol. 2000 Dec;106(6):1075-80. doi: 10.1067/mai.2000.110795.
Although mouse allergen is known to cause occupational asthma in laboratory workers, its potential significance in home environments has never been studied.
This study was designed to define the prevalence of mouse sensitivity and its relationship to mouse allergen exposure and disease activity in inner-city children with asthma.
A subset of 499 subjects from the National Cooperative Inner-City Asthma Study had dust samples adequate for mouse allergen analysis, as well as valid puncture skin test (PST) results. Data were analyzed to relate mouse allergen exposure and other risk factors to mouse sensitization and asthma morbidity.
Eighty-nine (18%) of the 499 children had a positive mouse skin test response. Children whose homes had mouse allergen levels above the median (1.60 microg/g) in the kitchen had a significantly higher rate of mouse sensitization (23% vs 11%, P =. 007). Atopy was also significantly related to mouse sensitization, with 40% of those with more than 4 positive PST responses having mouse sensitivity compared with 4% of those with no other positive PST responses (P <.0001). When atopy and exposure were considered together, 53% of those with more than 4 positive PST responses and allergen levels above the median had a positive PST response to mouse allergen compared with 22% of those with more than 4 positive PST responses and allergen levels below the median (P <.0001). The relationship among mouse allergen exposure, sensitization, and any measures of asthma morbidity was not statistically significant.
Mouse allergen may be an important indoor allergen in inner-city children with asthma, with exposure and atopy contributing to mouse sensitization.
尽管已知小鼠过敏原可导致实验室工作人员患职业性哮喘，但其在家庭环境中的潜在重要性从未得到研究。
本研究旨在确定城市内哮喘儿童对小鼠过敏的患病率及其与小鼠过敏原暴露和疾病活动的关系。
来自全国城市内哮喘合作研究的499名受试者的一个子集有足够的灰尘样本用于小鼠过敏原分析，以及有效的点刺皮肤试验（PST）结果。对数据进行分析，以将小鼠过敏原暴露和其他风险因素与小鼠致敏和哮喘发病率相关联。
499名儿童中有89名（18%）小鼠皮肤试验反应呈阳性。家中厨房小鼠过敏原水平高于中位数（1.60微克/克）的儿童，其小鼠致敏率显著更高（23%对11%，P = 0.007）。特应性也与小鼠致敏显著相关，4个以上PST阳性反应者中有40%对小鼠过敏，而无其他PST阳性反应者中这一比例为4%（P < 0.0001）。当同时考虑特应性和暴露情况时，4个以上PST阳性反应且过敏原水平高于中位数者中，53%对小鼠过敏原PST反应呈阳性，而4个以上PST阳性反应且过敏原水平低于中位数者中这一比例为22%（P < 0.0001）。小鼠过敏原暴露、致敏与任何哮喘发病率指标之间的关系无统计学意义。
小鼠过敏原可能是城市内哮喘儿童重要的室内过敏原，暴露和特应性促成小鼠致敏。
