Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, 111 T.W. Alexander Drive, Research Triangle Park, North Carolina, 27709, USA.
Independent Consult, Chapel Hill, NC, USA.
Curr Allergy Asthma Rep. 2018 Aug 20;18(10):52. doi: 10.1007/s11882-018-0805-7.
The review provides insight into recent findings on bedroom allergen exposures, primarily focusing on pet, pest, and fungal exposures.
Large-scale studies and improved exposure assessment technologies, including measurement of airborne allergens and of multiple allergens simultaneously, have extended our understanding of indoor allergen exposures and their impact on allergic disease. Practical, streamlined methods for exposure reduction have shown promise in some settings, and potential protective effects of early-life exposures have been further elucidated through the investigation of specific bacterial taxa. Advances in molecular allergology have yielded novel data on sensitization profiles and cross-reactivity. The role of indoor allergen exposures in allergic disease is complex and remains incompletely understood. Advancing our knowledge of various co-exposures, including the environmental and host microbiome, that interact with allergens in early life will be crucial for the development of efficacious interventions to reduce the substantial economic and social burden of allergic diseases including asthma.
本文主要关注宠物、害虫和真菌暴露，就卧室过敏原暴露的最新发现提供了深入见解。
大规模研究和改进的暴露评估技术，包括空气中过敏原和多种过敏原的同时测量，扩展了我们对室内过敏原暴露及其对过敏性疾病影响的理解。在某些情况下，用于减少暴露的实用、简化方法显示出了前景，并且通过对特定细菌分类群的研究进一步阐明了生命早期暴露的潜在保护作用。分子变态反应学的进展提供了关于致敏谱和交叉反应性的新数据。室内过敏原暴露在过敏性疾病中的作用是复杂的，目前仍不完全清楚。深入了解各种共存暴露（包括环境和宿主微生物组）与生命早期过敏原的相互作用，对于开发有效的干预措施以降低包括哮喘在内的过敏性疾病的巨大经济和社会负担至关重要。
