Hwang Bang Yeon, Roberts Sara K, Chadwick Lucas R, Wu Christine D, Kinghorn A Douglas
Program for Collaborative Research in the Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, USA.
Planta Med. 2003 Jul;69(7):623-7. doi: 10.1055/s-2003-41115.
Two new C-methyl flavonoids, 6,8-di- C-methylluteolin 7-methyl ether (1) and 6- C-methylluteolin 7-methyl ether (2), were isolated from a commercially available sample of the roots of Hydrastis canadensis, along with seven known compounds, berberine (3), beta-hydrastine (4), canadine (5), canadaline (6), isocorypalmine (7), canadinic acid (8), and beta-sitosterol 3- O-beta- D-glucoside (9). The structures of the new compounds 1 and 2 were elucidated on the basis of their spectral data including 1D and 2D NMR techniques. Of these isolates, berberine (3) and, to a lesser extent, 1 and 2, showed antimicrobial activity when evaluated against the oral pathogens Streptococcus mutans and Fusobacterium nucleatum. Berberine (3) exhibited an additive antimicrobial effect when tested against S. mutans in combination with 1.
从市售的白毛茛根样品中分离出两种新的C-甲基黄酮类化合物，6,8-二-C-甲基木犀草素7-甲基醚（1）和6-C-甲基木犀草素7-甲基醚（2），以及七种已知化合物，小檗碱（3）、β-白毛茛碱（4）、加拿大碱（5）、加拿大灵（6）、异紫堇杷明（7）、加拿大酸（8）和β-谷甾醇3-O-β-D-葡萄糖苷（9）。新化合物1和2的结构根据其光谱数据（包括一维和二维核磁共振技术）得以阐明。在这些分离物中, 小檗碱（3）以及在较小程度上的化合物1和2，在针对口腔病原体变形链球菌和具核梭杆菌进行评估时显示出抗菌活性。小檗碱（3）与1联合测试时，对变形链球菌表现出相加抗菌作用。
