Arzani Vida, Soleimani Mohsen, Fritsch Tilman, Jacob Ursula M, Calabrese Vittorio, Arzani Ahmad
School of Dentistry, Iran University of Medical Sciences, Tehran, Iran.
Department of Pharmacology, School of Medicine, AJA University of Medical Sciences, Tehran, Iran.
Open Med (Wars). 2025 Apr 15;20(1):20251183. doi: 10.1515/med-2025-1183. eCollection 2025.
Herbal products are increasingly being used for their potential to promote oral health. Phytochemicals can act as scavengers of reactive or toxic chemicals, selective growth factors for beneficial oral bacteria, fermentation substrates for beneficial oral bacteria, and selective inhibitors of harmful oral microflora. Plant-derived secondary metabolites encompass a variety of natural products, including alkaloids, polyphenols (including flavonoids and tannins), terpenes, terpenoids, steroids, saponins, quinones, coumarins, glycosides, and carotenoids.
This review explores medicinal plant-based products for preventing and treating oral diseases, offering updated insights into the scientific basis for using herbs as active ingredients in oral health care. Hence, we focused on: (1) phenolic compounds, the most abundant and common phytochemicals and (2) terpenes and terpenoids, the most diverse and widely distributed group in the plant kingdom.
Several databases were queried to acquire peer-reviewed studies focusing on the major phytochemical compositions - phenolic compounds, terpenes, and terpenoids - and their oral health benefits.
The review lists numerous medicinal herbs in various forms and applications for treating dental caries, gingivitis, and periodontitis.
This review explores the evidence supporting the oral health-promoting effects of specific constituents in herbs with the potential for incorporation into pharmaceutical formulations.
草药产品因其促进口腔健康的潜力而越来越多地被使用。植物化学物质可以作为活性或有毒化学物质的清除剂、有益口腔细菌的选择性生长因子、有益口腔细菌的发酵底物以及有害口腔微生物群的选择性抑制剂。植物衍生的次生代谢产物包括多种天然产物，如生物碱、多酚（包括黄酮类和单宁）、萜类、萜类化合物、类固醇、皂苷、醌类、香豆素、糖苷和类胡萝卜素。
本综述探讨了用于预防和治疗口腔疾病的药用植物基产品，为将草药用作口腔保健活性成分的科学依据提供了最新见解。因此，我们重点关注：（1）酚类化合物，这是最丰富和常见的植物化学物质；（2）萜类和萜类化合物，这是植物界中最多样化和分布最广的类别。
查询了几个数据库，以获取侧重于主要植物化学成分——酚类化合物、萜类和萜类化合物——及其口腔健康益处的同行评审研究。
该综述列出了多种形式和应用的多种草药，用于治疗龋齿、牙龈炎和牙周炎。
本综述探讨了支持草药中特定成分促进口腔健康作用的证据，这些成分有可能被纳入药物制剂中。
