Hegerl U, Prochno I, Ulrich G, Müller-Oerlinghausen B
Laboratory of Clinical Psychopharmacology, Free University of Berlin, F.R.G.
Biol Psychiatry. 1989 Jan 15;25(2):179-90. doi: 10.1016/0006-3223(89)90162-5.
The relationship between auditory evoked potentials (AEP) and the German version of Zuckerman's Sensation Seeking Scale was examined. The slope of the amplitude/stimulus intensity function (N1/P2 component) and the N1 latency were particularly studied, as these variables have been found to be potential predictors of the response to lithium prophylaxis. Thirty-three healthy subjects participated in two testing series on the first day and in a third run 3 weeks later. Binaural clicks at four intensity levels (58, 68, 78, 88 dB HL, ISI 2.1 sec) were presented in randomized order by headphone. Eighty responses were averaged at each intensity level. The pattern of correlation between the German version of the Sensation Seeking Scale and a personality inventory (FPI) supports the validity of the Sensation Seeking Scale. Only a tendency toward steeper slopes of the amplitude/stimulus intensity function (ASF) in high sensation seekers was observed in the first run. However, there was a significant interaction of sensation seeking and the test run. Only high sensation seekers showed an influence of retesting on the slope of the ASF, leading to a decrease of the slope in the second, compared with the first run. This might correspond to the psychological pattern of sensation seeking, which is characterized by a permanent need for new and exciting situations and, at the same time, by a rapid loss of interest in these situations. With regard to the N1 latency, a significant interaction of sensation seeking and lead was found. Low sensation seekers showed longer N1 latencies over the right than over the left hemisphere, a finding that accords with some psychophysiological theories on the relation between asymmetric hemispherical activation and certain psychological constructs. Our results support the view that sensation seeking is a personality feature that is closely related to certain physiological variables.
研究了听觉诱发电位（AEP）与德语版祖克曼感觉寻求量表之间的关系。特别研究了振幅/刺激强度函数（N1/P2成分）的斜率和N1潜伏期，因为这些变量已被发现是锂盐预防性治疗反应的潜在预测指标。33名健康受试者在第一天参加了两个测试系列，并在3周后进行了第三次测试。通过耳机以随机顺序呈现四个强度水平（58、68、78、88 dB HL，刺激间隔2.1秒）的双耳点击声。每个强度水平平均80次反应。德语版感觉寻求量表与一份人格问卷（FPI）之间的相关模式支持了感觉寻求量表的有效性。在第一次测试中，仅观察到高感觉寻求者的振幅/刺激强度函数（ASF）斜率有变陡的趋势。然而，感觉寻求与测试次数之间存在显著的交互作用。只有高感觉寻求者表现出重测对ASF斜率有影响，导致第二次测试时斜率相对于第一次测试有所下降。这可能与感觉寻求的心理模式相对应，其特点是持续需要新的和令人兴奋的情境，同时又对这些情境迅速失去兴趣。关于N1潜伏期，发现感觉寻求与导联之间存在显著的交互作用。低感觉寻求者右侧半球的N1潜伏期比左侧半球更长，这一发现与一些关于半球不对称激活与某些心理结构之间关系的心理生理学理论相符。我们的结果支持这样一种观点，即感觉寻求是一种与某些生理变量密切相关的人格特征。
