Li Dong-bing, Wang Jing-xia, Chang Bao-zhi, Huang Yan-ting, Xie Xiang-dong, Huang Yao-zhou, Wang Chang-shun, Chen Xi-lin, Li Quan, Wang Li-yong
Xiyuan Hospital, Chinese Academy of Traditional Chinese Medicine, Beijing 100091, China.
Zhonghua Yi Xue Za Zhi. 2003 Jun 10;83(11):958-61.
To observe the effect of copper ion electrochemistry (CIE) in treatment of bleeding and prolapse due to hemorrhoid.
Bleeding was caused at several points on the sacrospinal muscles of 26 rabbits. Routine hemostasis was used at one side (control side) and CIE was used on the opposite side (experimental side). The stanch times at the different sides were recorded. Then the rabbits were killed. Pathological examination was made to the lung, liver, and kidney to observe the amount of small thrombus and inflammation. CIE was performed at the right side of anus of 6 dogs and the right side was used as control side. Tissue specimens of rabbit muscle and dog anus mucosa were collected to examine the copper ion concentration. A copper needle was inserted into each pile to the depth of 10 - 15 mm for 4'40" (with the mean number of treated points of 9.8) upon 202 patients suffering from bleeding due to hemorrhoid, 79 with inner hemorrhoids and 123 patients with mixed hemorrhoids (experimental group). Another 171 patients suffering from bleeding due to hemorrhoid, 64 with inner hemorrhoids and 107 with mixed hemorrhoids were treated with suppository as controls. CEI was performed on 128 patients suffering from prolapse of hemorrhoid, 41 with inner hemorrhoids and 87 with mixed hemorrhoids (experimental group). Another 115 patients suffering from prolapse of hemorrhoid, 40 with inner hemorrhoids and 75 with mixed hemorrhoids were treated with suppository as controls. Biopsy specimens of anus mucosa were taken from 18 patients with mixed hemorrhoid who underwent CIE. The copper ion concentration was measured in 30 patients undergoing CIE.
The stanch time in the experimental side of rabbit was (1.16 +/- 0.18) min, significantly shorter than that in the control side [(2.13 +/- 0.46) min, P = 0.0037]. Extensive small thrombi and edema of vascular wall were seen in the rabbit liver, lung, kidney, and muscle tissues in comparison with the tissues of the control side (P < 0.01). Copper ion complex was seen in the experimental rabbit tissues. The copper ion concentration was significantly higher in the experimental area of dog anus mucosa than in the control area. Clinical study showed that after CIE the curative rate for bleeding was 95.5%, significantly higher than that of the control group (8.8%, U = 44.6, P < 0.001). The curative rate for prolapse in the experimental group was 60.8%, significantly higher than that of the control group (20.9%, U = 313.2, P < 0.01). No patient felt pain while treated and later. After the CIE treatment, the patients only needed to take a rest for 4 hours. Pathology showed there were much more small thrombi in the treated tissues. The blood copper ion concentration in the trial group did not increase significantly after CIE in comparison with that before treatment.
CIE is safe, effective and easy to perform in treatment of bleeding and prolapse due to hemorrhoid.
观察铜离子电化学疗法（CIE）治疗痔出血及脱垂的效果。
在26只兔的骶棘肌多处造成出血。一侧（对照侧）采用常规止血法，另一侧（实验侧）采用CIE。记录不同侧的止血时间。然后处死兔子。对肺、肝和肾进行病理检查，观察小血栓和炎症情况。对6只犬的肛门右侧进行CIE，右侧作为对照侧。采集兔肌肉和犬肛门黏膜组织标本检测铜离子浓度。对202例痔出血患者（79例内痔、123例混合痔，实验组），每处痔核插入铜针至10 - 15 mm深度，持续4分40秒（平均治疗点数9.8个）。另171例痔出血患者（64例内痔、107例混合痔）采用栓剂治疗作为对照。对128例痔脱垂患者（41例内痔、87例混合痔，实验组）进行CIE。另115例痔脱垂患者（40例内痔、75例混合痔）采用栓剂治疗作为对照。对18例接受CIE的混合痔患者取肛门黏膜活检标本。对30例接受CIE的患者检测铜离子浓度。
兔实验侧止血时间为（1.16±0.18）分钟，显著短于对照侧[（2.13±0.46）分钟，P = 0.0037]。与对照侧组织相比，兔肝、肺、肾及肌肉组织可见广泛小血栓及血管壁水肿（P < 0.01）。实验兔组织中可见铜离子复合物。犬肛门黏膜实验区铜离子浓度显著高于对照区。临床研究表明，CIE后出血治愈率为95.5%，显著高于对照组（8.8%，U = 44.6，P < 0.001）。实验组脱垂治愈率为60.8%，显著高于对照组（20.9%，U = 313.2，P < 0.01）。治疗过程中及治疗后患者均无疼痛感觉。CIE治疗后患者仅需休息4小时。病理显示治疗组织中小血栓更多。实验组CIE后血铜离子浓度与治疗前相比无显著升高。
CIE治疗痔出血及脱垂安全、有效且操作简便。
