Khosla S N
Am J Med Sci. 1975 Nov-Dec;270(3):475-80. doi: 10.1097/00000441-197511000-00008.
Most articles on Friedreich's ataxia report that cardiac complications are almost universal in patients with this disease. However, the present study of 30 cases, observed for two to ten years, seems to belie the experience of other writers in the field. Only six (20 per cent) of these patients showed electrocardiographic abnormalities. Only one patient had cardiac enlargement and congestive heart failure. One other patient had paroxysmal tachycardia. Seventy-four family members were also studied and the results were similar. It is suggested that this impressive difference may be a racial one and indeed very few reports on Friedreich's ataxia have come from India. Further study of this group of patients is in progress. The author also includes a review of the literature of neuromyopathic diseases and their relationship to myocardial involvement.
大多数关于弗里德赖希共济失调的文章都报道，这种疾病的患者几乎普遍存在心脏并发症。然而，本项对30例患者进行了两到十年观察的研究，似乎与该领域其他作者的经验相悖。这些患者中只有6例（20%）出现心电图异常。只有1例患者有心脏扩大和充血性心力衰竭。另有1例患者有阵发性心动过速。还对74名家庭成员进行了研究，结果相似。有人认为，这种显著差异可能与种族有关，而且确实很少有来自印度的关于弗里德赖希共济失调的报道。对这组患者的进一步研究正在进行中。作者还对神经肌肉疾病的文献及其与心肌受累的关系进行了综述。
