Lu Wei-xuan, Zhang Yi-jie, Hu Bo, Ma Yi, Zhu Yuan-jue
Department of Pulmonary Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing 100730, China.
Zhonghua Jie He He Hu Xi Za Zhi. 2003 Apr;26(4):195-8.
To study the value of St George's respiratory questionnaire (SGRQ) in evaluating the life quality of Chinese patients with COPD.
The SGRQ score and spirometry were collected from 30 patients with COPD. The validity was documented by performing correlation analysis, and Pearson's correlation coefficients were calculated. Nineteen patients were reassessed after three months' treatment with inhaled glucocorticoids. Paired t test was performed to evaluate the sensitivity of SGRQ to changes of disease severity.
The correlation coefficients between the total score and the symptoms section score, the activity section score, and the impacts section score of SGRQ were 0.61, 0.79 and 0.97, respectively. The symptoms section score, the activity section score, the impacts section score, and the total score were significantly correlated with FEV(1)% pred, and with similar coefficients (-0.4 - -0.5, P < 0.05). The result of paired t test showed that the changes of SGRQ between the two assessments were significant (P < 0.001) and consistent with changes of clinical symptoms and spirometry. SGRQ was more sensitive than spirometry in evaluating the changes of disease severity.
SGRQ was a valid, sensitive and feasible method in measuring the quality of life in Chinese patients with COPD. Large-scale application in China needs to be carried out.
探讨圣乔治呼吸问卷（SGRQ）对评估中国慢性阻塞性肺疾病（COPD）患者生活质量的价值。
收集30例COPD患者的SGRQ评分及肺功能测定结果。通过相关性分析进行效度验证，并计算Pearson相关系数。19例患者经吸入糖皮质激素治疗3个月后重新评估。采用配对t检验评估SGRQ对疾病严重程度变化的敏感性。
SGRQ总分与症状部分评分、活动部分评分及影响部分评分的相关系数分别为0.61、0.79和0.97。症状部分评分、活动部分评分、影响部分评分及总分与预计第1秒用力呼气容积百分比（FEV(1)% pred）显著相关，且相关系数相近（-0.4至-0.5，P < 0.05）。配对t检验结果显示，两次评估间SGRQ的变化具有显著性（P < 0.001），且与临床症状及肺功能测定结果的变化一致。SGRQ在评估疾病严重程度变化方面比肺功能测定更敏感。
SGRQ是一种有效、敏感且可行的评估中国COPD患者生活质量的方法。在中国需要开展大规模应用。
