Chakhparonian Mikhail, Wellinger Raymund J
Department of Microbiology and Infectiology, Faculty of Medicine, Université de Sherbrooke, 3001 12th Ave N., Sherbrooke (QC), Canada J1H 5N4.
Trends Genet. 2003 Aug;19(8):439-46. doi: 10.1016/S0168-9525(03)00135-5.
The maintenance of the DNA at chromosome ends, the telomeres, depends on conventional semiconservative replication and on the action of telomerase, a specialized reverse transcriptase. Current research strongly suggests a regulatory interplay between this conventional semiconservative replication and telomerase, thus ensuring that no sequences are lost at the very ends of the telomeres during replication. Here, we describe recent findings on the interactions between the conventional replication machinery and telomere replication, and we discuss how DNA-integrity checkpoints might impinge on both the processing of the telomeric DNA ends and the establishment of the DNA end structure required for end protection and genome stability.
染色体末端的端粒处DNA的维持依赖于传统的半保留复制以及端粒酶（一种特殊的逆转录酶）的作用。当前研究有力地表明，这种传统的半保留复制与端粒酶之间存在调控相互作用，从而确保在复制过程中端粒最末端的序列不会丢失。在此，我们描述了关于传统复制机制与端粒复制之间相互作用的最新发现，并讨论了DNA完整性检查点如何可能影响端粒DNA末端的处理以及建立末端保护和基因组稳定性所需的DNA末端结构。
