[诱导型一氧化氮合酶在人食管癌及癌前病变活检组织中的表达]
[Expression of inducible nitric oxide synthase in human esophageal biopsies from carcinoma and precancerous lesions].
作者信息
Jin Y, Zhang W, Liu B, Wang H, Han Z, Wang L, Liu Y, Jin Y, Qu P, Li M, Ding Z, Lin P
机构信息
Detection Center of Tumor Biology, Cancer Institute, CAMS and PUMC, Beijing 100021, China.
出版信息
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2000 Dec;22(6):570-2.
OBJECTIVE
To investigate the possible role of inducible nitric oxide synthase (iNOS) in esophageal carcinogenesis.
METHODS
iNOS expressions in normal epithelial cells(NC), hyperplastic cells(HC), atypical hyperplastic cells(AHC) from grade I to III, carcinoma in situ(CIS), squamous cell carcinoma(SCC), and adenocarcinoma(ADC) were detected with immunohistochemistry.
RESULTS
The positive rates of immunohistochemistry staining was 0 for NC, 2.5% for HC, 4.0%, 7.5% and 2.5% for AHC grade I to III respectively, 1.4% for CIS, 8.5% for SCC and 71.4% for ADC.
CONCLUSIONS
There is a high expression of iNOS in human esophageal adenocarcinomas. Frequent expression of iNOS may be a potential event in ADC carcinogenesis. There is no correlation between iNOS and SCC carcinogenesis.
目的
探讨诱导型一氧化氮合酶（iNOS）在食管癌发生中的可能作用。
方法
采用免疫组织化学法检测正常上皮细胞（NC）、增生细胞（HC）、I至III级非典型增生细胞（AHC）、原位癌（CIS）、鳞状细胞癌（SCC）和腺癌（ADC）中iNOS的表达。
结果
免疫组织化学染色阳性率在NC中为0，HC中为2.5%，I至III级AHC中分别为4.0%、7.5%和2.5%，CIS中为1.4%，SCC中为8.5%，ADC中为71.4%。
结论
iNOS在人食管腺癌中高表达。iNOS的频繁表达可能是ADC发生中的一个潜在事件。iNOS与SCC发生无相关性。
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