Messaritakis J, Kattamis C, Karabula C, Matsaniotis N
Arch Dis Child. 1975 Nov;50(11):871-4. doi: 10.1136/adc.50.11.871.
Twenty-five infants with generalized seborrhoeic dermatitis have been studied with reference to the provision of optimum treatment. Leucocyte counts and chest x-ray examination are recommended in every case. Irrespective of clinical findings, antibiotics should be given to patients with overt bacterial infection and those with leucocytosis, shift to the left, and toxic granulation. One group of infants was treated with vitamin B complex plus biotin given slowly intravenously over 24 hours; a second group was given only biotin intravenously over 2-3 hours; and a third group only biotin over 1-2 minutes. A fourth group was treated with both biotin and antibiotics for confirmed or suspected superimposed bacterial infection. The results were excellent in all groups. Skin lesions improved within 4-8 days and cleared completely within 15-30 days. Intravenous administration of biotin is recommended as less painful and less dangerous than multiple intramuscular injections.
对25例泛发性脂溢性皮炎婴儿进行了研究，以探讨最佳治疗方法。建议对每例患儿进行白细胞计数和胸部X光检查。无论临床表现如何，对于有明显细菌感染以及白细胞增多、核左移和中毒性颗粒的患者，均应给予抗生素治疗。一组婴儿接受复合维生素B加生物素治疗，通过静脉在24小时内缓慢给药；第二组仅在2至3小时内静脉给予生物素；第三组仅在1至2分钟内给予生物素。第四组针对确诊或疑似合并细菌感染的患儿，同时给予生物素和抗生素治疗。所有组的治疗效果均极佳。皮肤损害在4至8天内改善，并在15至30天内完全消退。建议静脉注射生物素，因为其比多次肌肉注射疼痛轻且危险性小。
