Zagursky Robert J, Anderson Annaliesa S
Vaccine Discovery Research, Wyeth, 401 North Middletown Road, Pearl River, NY 10965, USA.
Curr Opin Pharmacol. 2008 Oct;8(5):632-8. doi: 10.1016/j.coph.2008.06.009. Epub 2008 Jul 24.
The combined power of genomics and proteomics has led to many advances in the discovery of bacterial vaccine targets. The 'Holy Grail' for a vaccine is to be pathogen specific yet conserved among all strains, so that universal coverage is possible with the minimal number of antigens. Genomics allows us to target conserved proteins, while proteomics tells us what is actually expressed and what is accessible to antibodies. Achievements using these latest approaches are exemplified by the vaccine clinical trials that are ongoing for protein targets against Neiserria meningitidis and Staphylococcus aureus along with promising discoveries that have been made for other pathogens including Streptococcus pneumoniae and Streptococcus pyogenes. These developments are discussed in this review.
基因组学和蛋白质组学的联合力量已在细菌疫苗靶点的发现方面带来了许多进展。疫苗的“圣杯”是具有病原体特异性且在所有菌株中都保守，以便能用最少数量的抗原实现普遍覆盖。基因组学使我们能够针对保守蛋白，而蛋白质组学则告诉我们实际表达的是什么以及抗体能够接触到什么。针对脑膜炎奈瑟菌和金黄色葡萄球菌的蛋白质靶点正在进行的疫苗临床试验，以及针对包括肺炎链球菌和化脓性链球菌在内的其他病原体所取得的有前景的发现，例证了使用这些最新方法所取得的成就。本综述将讨论这些进展。
