Farver Debra K
South Dakota State University, South Dakota Human Services Center, PO Box 76, Yankton, SD 57078, USA.
Expert Opin Drug Saf. 2003 Jan;2(1):21-35. doi: 10.1517/14740338.2.1.21.
A review of the English literature confirms that neuroleptic malignant syndrome (NMS) occurs with both traditional and atypical antipsychotic medications. Published reports of NMS induced by the traditional antipsychotics have given the practitioner valuable information on the prevention and treatment of this adverse effect. Case reports have also been published concerning NMS and clozapine, risperidone, olanzapine and quetiapine. By evaluating the case reports of atypical antipsychotic-induced NMS, valuable information may be obtained concerning similarities or differences from that induced by the traditional antipsychotics. The case reports of NMS with atypical antipsychotics were evaluated for diagnosis, age/sex of patient, risk factors, antipsychotic doses and duration of use, symptoms of NMS, and clinical course.
对英文文献的回顾证实，传统抗精神病药物和非典型抗精神病药物都可引发神经阻滞剂恶性综合征（NMS）。关于传统抗精神病药物所致NMS的已发表报告为临床医生提供了有关预防和治疗这种不良反应的宝贵信息。也有关于NMS与氯氮平、利培酮、奥氮平和喹硫平的病例报告发表。通过评估非典型抗精神病药物所致NMS的病例报告，可获得有关其与传统抗精神病药物所致NMS异同的宝贵信息。对非典型抗精神病药物所致NMS的病例报告进行了诊断、患者年龄/性别、危险因素、抗精神病药物剂量及使用时长、NMS症状和临床病程等方面的评估。
