Nicollier-Jamot Béatrice, Pico Valérie, Pothier Pierre, Kohli Evelyne
Microbiologie Médicale et Moléculaire, Facultés de Médecine et Pharmacie, Université de Bourgogne, 21033 Dijon cedex, France.
J Clin Microbiol. 2003 Aug;41(8):3901-4. doi: 10.1128/JCM.41.8.3901-3904.2003.
Virus-like particles of Dijon171/96 virus, a genogroup II norovirus, were expressed in a baculovirus system and were used for a seroepidemiological study of 1078 age-stratified human sera collected in Dijon, France. The results showed a seroprevalence of 74.1%. Furthermore, we showed that murine antibodies generated against recombinant Dijon171/96 virus, and human antibodies recognized discontinuous epitopes on the particles.
第II基因组诺如病毒第戎171/96病毒的病毒样颗粒在杆状病毒系统中表达,并用于对在法国第戎收集的1078份按年龄分层的人血清进行血清流行病学研究。结果显示血清阳性率为74.1%。此外,我们还表明,针对重组第戎171/96病毒产生的鼠抗体以及人抗体识别颗粒上的不连续表位。