丙型肝炎病毒向抗人类免疫缺陷病毒阴性母亲的婴儿的垂直传播：产前、围产期或产后感染中高变区1的分子进化
Vertical transmission of the hepatitis C virus to infants of anti-human immunodeficiency virus-negative mothers: molecular evolution of hypervariable region 1 in prenatal and perinatal or postnatal infections.
作者信息
Caudai C, Battiata M, Riccardi M P, Toti M, Bonazza P, Padula M G, Pianese M, Valensin P E
机构信息
Department of Molecular Biology, Microbiology Section, University of Siena, Siena, Italy.
出版信息
J Clin Microbiol. 2003 Aug;41(8):3955-9. doi: 10.1128/JCM.41.8.3955-3959.2003.
Abstract
In a prospective study of 33 infants born to hepatitis C virus (HCV)-positive human immunodeficiency virus-negative mothers the vertical transmission of HCV occurred in 6.8%. The evolution of HCV infection in two babies was studied from birth up to 5 or 6 years of age, and the sequencing of the hypervariable region (HVR) of the putative envelope-encoding E2 region of the HCV genome was performed. The HVR1 sequence variability and the different serological profiles during follow-up could reflect the differences in HCV transmission routes, HCV genotypes, and clinical evolution of infection.
摘要
在一项对33名丙型肝炎病毒（HCV）阳性、人类免疫缺陷病毒阴性母亲所生婴儿的前瞻性研究中，HCV垂直传播发生率为6.8%。对两名婴儿从出生到5或6岁的HCV感染演变情况进行了研究，并对HCV基因组假定的包膜编码E2区高变区（HVR）进行了测序。随访期间HVR1序列变异性和不同的血清学特征可反映HCV传播途径、HCV基因型以及感染临床演变的差异。
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