[2型糖尿病中的非糖尿病肾病]

[Non-diabetic renal disease in type II diabetes mellitus].

作者信息

Li Hang, Li Xue-wang, Huang Qing-yuan, Ye Wen-ling, Duan Lin, Li Yan

机构信息

Department of Nephropathy, PUMC Hospital, CAMS, PUMC, Beijing 100730, China.

出版信息

Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2003 Feb;25(1):101-4.

PMID:12905620

Abstract

OBJECTIVE

Several studies have suggested that non-diabetic renal disease (NDRD) was common among non-insulin dependent diabetes mellitus (NIDDM) patients with renal involvement.

METHODS

The prevalence of NDRD among Chinese NIDDM population in PUMC hospital center was retrospectively studied. Renal biopsy specimens were evaluated with light-, immunofluorescence- and electron-microscopy. The cohort consisted of 33 NIDDM patients who received renal biopsy.

RESULTS

Patients with both isolated diabetic nephropathy (DN, n = 7) and NDRD (n = 22) had comparable duration of DM, creatinine clearance, serum creatinine, albumin and 24 hours proteinuria, as well as incidences of retinopathy, neuropathy and hypertension. Significantly more patients with NDRD had haematuria (P = 0.030) or non-nephrotic proteinuria (P = 0.016). IgA nephropathy accounted for 40.9% of the NDRD identified.

CONCLUSIONS

In this study, haematuria and non-nephrotic proteinuria predicted the presence of NDRD among NIDDM patients complicated with renal disease. IgA nephropathy is the most frequent type of NDRD in Chinese.

摘要

目的

多项研究表明，非糖尿病肾病（NDRD）在非胰岛素依赖型糖尿病（NIDDM）合并肾脏受累的患者中很常见。

方法

回顾性研究中国医学科学院北京协和医院中心NIDDM人群中NDRD的患病率。对肾活检标本进行光镜、免疫荧光和电镜评估。该队列由33例接受肾活检的NIDDM患者组成。

结果

孤立性糖尿病肾病（DN，n = 7）和NDRD（n = 22）患者的糖尿病病程、肌酐清除率、血清肌酐、白蛋白和24小时蛋白尿，以及视网膜病变、神经病变和高血压的发生率相当。NDRD患者出现血尿（P = 0.030）或非肾病性蛋白尿（P = 0.016）的比例明显更高。IgA肾病占已确诊NDRD的40.9%。