Thornton Venita B, Davis Judith A, St Clair Mark B, Cole Marlene N
Uniformed Services University of the Health Sciences (USUHS), 4301 Jones Bridge Road, Bethesda, MD 20814, USA.
Contemp Top Lab Anim Sci. 2003 Jul;42(4):49-52.
An experimental study was performed to investigate whether intradermal tail inoculations of Staphylococcus xylosus would result in pathologic lesions in the SJL/J strain of mice (Mus musculus). This organism historically has been classified as a nonpathogenic, commensal bacterium associated with skin and mucous membranes and rarely implicated in infections. In this study, SJL/J mice inoculated with S. xylosus developed cutaneous tail lesions post-inoculation, and the organism was recovered from those lesions. Inoculation was accomplished by surgically inserting silk suture impregnated with the concentrated suspension of bacteria. In addition, a superficial abrasion was created adjacent to the suture, and a bacterial suspension was applied. Approximately 80% of the mice in the inoculated groups developed dermatologic lesions, compared with 0% in the control group. Mice with lesions were treated with Sulfamethoxazole-Trimethoprim in the drinking water continuously for 28 days. For the mice assigned to the treatment group, this treatment resulted in resolution of the cutaneous tail lesions.
进行了一项实验研究，以调查皮内接种木糖葡萄球菌是否会在SJL/J品系小鼠（小家鼠）中导致病理损伤。从历史上看，这种微生物一直被归类为与皮肤和粘膜相关的非致病性共生细菌，很少与感染有关。在本研究中，接种木糖葡萄球菌的SJL/J小鼠在接种后出现了尾部皮肤损伤，并且从这些损伤中分离出了该微生物。接种是通过手术插入浸渍有细菌浓缩悬浮液的丝线来完成的。此外，在缝线附近造成浅表擦伤，并应用细菌悬浮液。接种组中约80%的小鼠出现了皮肤损伤，而对照组为0%。对有损伤的小鼠持续28天在饮用水中给予磺胺甲恶唑-甲氧苄啶治疗。对于分配到治疗组的小鼠，这种治疗导致尾部皮肤损伤消退。
