• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

噬菌体疗法:我们学到了什么?

Phage Therapy: What Have We Learned?

机构信息

Bacteriophage Laboratory, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Rudolfa Weigla Street 12, 53-114 Wroclaw, Poland.

Phage Therapy Unit, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Rudolfa Weigla Street 12, 53-114 Wroclaw, Poland.

出版信息

Viruses. 2018 May 28;10(6):288. doi: 10.3390/v10060288.

DOI:10.3390/v10060288
PMID:29843391
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6024844/
Abstract

In this article we explain how current events in the field of phage therapy may positively influence its future development. We discuss the shift in position of the authorities, academia, media, non-governmental organizations, regulatory agencies, patients, and doctors which could enable further advances in the research and application of the therapy. In addition, we discuss methods to obtain optimal phage preparations and suggest the potential of novel applications of phage therapy extending beyond its anti-bacterial action.

摘要

本文旨在阐述噬菌体疗法领域的当前形势将如何积极影响其未来发展。我们探讨了相关各方(包括当局、学术界、媒体、非政府组织、监管机构、患者和医生)立场的转变,这些转变将有助于推动该疗法的研究和应用。此外,我们还讨论了获得最佳噬菌体制剂的方法,并提出了噬菌体疗法潜在的新型应用,超越其抗菌作用。

相似文献

1
Phage Therapy: What Have We Learned?噬菌体疗法:我们学到了什么?
Viruses. 2018 May 28;10(6):288. doi: 10.3390/v10060288.
2
Current challenges and future opportunities of phage therapy.噬菌体疗法的当前挑战与未来机遇
FEMS Microbiol Rev. 2020 Nov 24;44(6):684-700. doi: 10.1093/femsre/fuaa017.
3
Phage therapy: Current status and perspectives.噬菌体疗法:现状与展望。
Med Res Rev. 2020 Jan;40(1):459-463. doi: 10.1002/med.21593. Epub 2019 May 7.
4
Expert Opinion on Three Phage Therapy Related Topics: Bacterial Phage Resistance, Phage Training and Prophages in Bacterial Production Strains.专家观点:三个噬菌体治疗相关主题:细菌噬菌体耐药性、噬菌体训练和细菌生产菌株中的原噬菌体。
Viruses. 2018 Apr 5;10(4):178. doi: 10.3390/v10040178.
5
Formulation, stabilisation and encapsulation of bacteriophage for phage therapy.噬菌体的制剂学、稳定性和包封用于噬菌体治疗。
Adv Colloid Interface Sci. 2017 Nov;249:100-133. doi: 10.1016/j.cis.2017.05.014. Epub 2017 May 14.
6
Bacteriophages as a potential substitute for antibiotics: A comprehensive review.噬菌体作为抗生素的潜在替代品:全面综述。
Cell Biochem Funct. 2024 Apr;42(3):e4022. doi: 10.1002/cbf.4022.
7
Bacteriophages as Therapeutic Preparations: What Restricts Their Application in Medicine.噬菌体作为治疗制剂:限制其在医学中应用的因素。
Biochemistry (Mosc). 2020 Nov;85(11):1350-1361. doi: 10.1134/S0006297920110061.
8
Effectiveness of Bacteriophage Therapy in Field Conditions and Possible Future Applications.噬菌体疗法在现场条件下的有效性及未来可能的应用。
Curr Pharm Biotechnol. 2020;21(5):364-373. doi: 10.2174/1389201021666191217111156.
9
Review article: bacteriophages in gastroenterology-from biology to clinical applications.综述文章:消化内科中的噬菌体——从生物学到临床应用。
Aliment Pharmacol Ther. 2020 Jan;51(1):53-63. doi: 10.1111/apt.15557. Epub 2019 Nov 7.
10
Advances in the field of phage-based therapy with special emphasis on computational resources.基于噬菌体的治疗领域的进展,特别强调计算资源。
Brief Bioinform. 2023 Jan 19;24(1). doi: 10.1093/bib/bbac574.

引用本文的文献

1
Bacteriophage Therapy: Discovery, Development, and FDA Approval Pathways.噬菌体疗法:发现、发展及美国食品药品监督管理局批准途径
Pharmaceuticals (Basel). 2025 Jul 26;18(8):1115. doi: 10.3390/ph18081115.
2
Recent insights on challenges encountered with phage therapy against gastrointestinal-associated infections.噬菌体疗法治疗胃肠道相关感染所面临挑战的最新见解。
Gut Pathog. 2025 Aug 11;17(1):60. doi: 10.1186/s13099-025-00735-y.
3
Comparative analysis of immune responses to intraperitoneal administration of lytic E. coli bacteriophages in mice.小鼠腹腔注射溶菌性大肠杆菌噬菌体后免疫反应的比较分析
Virus Res. 2025 Jul 19;359:199610. doi: 10.1016/j.virusres.2025.199610.
4
Multisite binding of bacteriophages on lipopolysaccharides in O157:H7 and the adaptive costs of phage resistance.噬菌体在O157:H7脂多糖上的多位点结合及噬菌体抗性的适应性代价。
Microbiol Spectr. 2025 Aug 5;13(8):e0006725. doi: 10.1128/spectrum.00067-25. Epub 2025 Jun 17.
5
Cytokines Meet Phages: A Revolutionary Pathway to Modulating Immunity and Microbial Balance.细胞因子与噬菌体相遇:调节免疫和微生物平衡的革命性途径。
Biomedicines. 2025 May 15;13(5):1202. doi: 10.3390/biomedicines13051202.
6
Overcoming in Chronic Suppurative Lung Disease: Prevalence, Treatment Challenges, and the Promise of Bacteriophage Therapy.慢性化脓性肺病的攻克:患病率、治疗挑战及噬菌体疗法的前景
Antibiotics (Basel). 2025 Apr 23;14(5):427. doi: 10.3390/antibiotics14050427.
7
Bacteriophage therapy for multidrug-resistant infections: current technologies and therapeutic approaches.用于多重耐药感染的噬菌体疗法:当前技术与治疗方法
J Clin Invest. 2025 Mar 3;135(5):e187996. doi: 10.1172/JCI187996.
8
Safety and tolerability of bronchoscopic and nebulised administration of bacteriophage.经支气管镜和雾化给药的噬菌体的安全性和耐受性。
Virus Res. 2024 Oct;348:199442. doi: 10.1016/j.virusres.2024.199442. Epub 2024 Jul 31.
9
Isolation and characterisation of a novel Silviavirus bacteriophage promising antimicrobial agent against methicillin-resistant Staphylococcus aureus infections.分离和鉴定一种新型 Silvia 噬菌体,有望成为治疗耐甲氧西林金黄色葡萄球菌感染的抗菌药物。
Sci Rep. 2024 Apr 22;14(1):9251. doi: 10.1038/s41598-024-59903-w.
10
Harnessing filamentous phages for enhanced stroke recovery.利用丝状噬菌体促进中风康复。
Front Immunol. 2024 Jan 16;14:1343788. doi: 10.3389/fimmu.2023.1343788. eCollection 2023.

本文引用的文献

1
An online phage therapy bibliography: separating under-indexed wheat from overly indexed chaff.一份在线噬菌体疗法文献目录:区分索引不足的麦粒与索引过度的谷壳。
AIMS Microbiol. 2017 Jun 27;3(3):525-528. doi: 10.3934/microbiol.2017.3.525. eCollection 2017.
2
Phage Therapy: Beyond Antibacterial Action.噬菌体疗法:超越抗菌作用
Front Med (Lausanne). 2018 May 23;5:146. doi: 10.3389/fmed.2018.00146. eCollection 2018.
3
Silk Route to the Acceptance and Re-Implementation of Bacteriophage Therapy-Part II.噬菌体疗法被接受与重新应用的丝绸之路——第二部分
Antibiotics (Basel). 2018 Apr 23;7(2):35. doi: 10.3390/antibiotics7020035.
4
Expert Opinion on Three Phage Therapy Related Topics: Bacterial Phage Resistance, Phage Training and Prophages in Bacterial Production Strains.专家观点:三个噬菌体治疗相关主题:细菌噬菌体耐药性、噬菌体训练和细菌生产菌株中的原噬菌体。
Viruses. 2018 Apr 5;10(4):178. doi: 10.3390/v10040178.
5
Optimizing Propagation of Staphylococcus aureus Infecting Bacteriophage vB_SauM-phiIPLA-RODI on Staphylococcus xylosus Using Response Surface Methodology.利用响应面法优化感染葡萄球菌噬菌体 vB_SauM-phiIPLA-RODI 在木糖葡萄球菌上的繁殖。
Viruses. 2018 Mar 27;10(4):153. doi: 10.3390/v10040153.
6
Contemporary Phage Biology: From Classic Models to New Insights.当代噬菌体生物学:从经典模型到新视角。
Cell. 2018 Mar 8;172(6):1260-1270. doi: 10.1016/j.cell.2017.10.045.
7
Efficient and Scalable Precision Genome Editing in through Conditional Recombineering and CRISPR/Cas9-Mediated Counterselection.通过条件重组和 CRISPR/Cas9 介导的反筛选实现 的高效可扩展精确基因组编辑。
mBio. 2018 Feb 20;9(1):e00067-18. doi: 10.1128/mBio.00067-18.
8
The Magistral Phage.《御用药用噬菌体》
Viruses. 2018 Feb 6;10(2):64. doi: 10.3390/v10020064.
9
Use of a Regression Model to Study Host-Genomic Determinants of Phage Susceptibility in MRSA.使用回归模型研究耐甲氧西林金黄色葡萄球菌中噬菌体敏感性的宿主基因组决定因素。
Antibiotics (Basel). 2018 Jan 29;7(1):9. doi: 10.3390/antibiotics7010009.
10
Phage therapy in allergic disorders?噬菌体疗法在过敏疾病中的应用?
Exp Biol Med (Maywood). 2018 Mar;243(6):534-537. doi: 10.1177/1535370218755658. Epub 2018 Jan 23.