Hernández Domingo, de la Rosa Alejandro, Barragán Antonio, Barrios Ysamar, Salido Eduardo, Torres Armando, Martín Basilio, Laynez Ignacio, Duque Amelia, De Vera Antonia, Lorenzo Victor, González Antonio
Service of Nephrology, Hospital Universitario de Canarias e Instituto Reina Sofía de Investigación, La Laguna, Tenerife, Spain.
J Am Coll Cardiol. 2003 Aug 6;42(3):527-32. doi: 10.1016/s0735-1097(03)00642-9.
We studied the impact of the angiotensin-converting enzyme (ACE)/DD genotype on morphologic and functional cardiac changes in adult endurance athletes.
Trained athletes usually develop adaptive left ventricular hypertrophy (LVH), and ACE gene polymorphisms may regulate myocardial growth. However, little is known about the impact of the ACE/DD genotype and D allele dose on the cardiac changes in adult endurance athletes. METHODS; Echocardiographic studies (including tissue Doppler) were performed in 61 male endurance athletes ranging in age from 25 to 40 years, with a similar period of training (15.6 +/- 4 h/week for 12.6 +/- 5.7 years). The ACE genotype (insertion [I] or deletion [D] alleles) was ascertained by polymerase chain reaction (DD = 27, ID = 31, and II = 3). Athletes with the DD genotype were compared with their ID counterparts.
The DD genotype was associated with a higher left ventricular mass index (LVMI) than the ID genotype (162.6 +/- 36.5 g/m(2) vs. 141.6 +/- 34 g/m(2), p = 0.031), regardless of other confounder variables. As a result, 70.4% of DD athletes and only 42% of ID athletes met the criteria for LVH (p = 0.037). Although systolic and early diastolic myocardial velocities were similar in DD and ID subjects, a more prolonged E-wave deceleration time (DT) was observed in DD as compared with ID athletes, after adjusting for other biologic variables (210 +/- 48 ms vs. 174 +/- 36 ms, respectively; p = 0.008). Finally, a positive association between DT and myocardial systolic peak velocity (medial and lateral peak S(m)) was only observed in DD athletes (p = 0.013, r = 0.481).
The ACE/DD genotype is associated with the extent of exercise-induced LVH in endurance athletes, regardless of other known biologic factors.
我们研究了血管紧张素转换酶（ACE）/DD基因型对成年耐力运动员心脏形态和功能变化的影响。
训练有素的运动员通常会出现适应性左心室肥厚（LVH），而ACE基因多态性可能调节心肌生长。然而，关于ACE/DD基因型和D等位基因剂量对成年耐力运动员心脏变化的影响知之甚少。方法：对61名年龄在25至40岁之间、训练时间相似（12.6±5.7年，每周15.6±4小时）的男性耐力运动员进行了超声心动图研究（包括组织多普勒）。通过聚合酶链反应确定ACE基因型（插入[I]或缺失[D]等位基因）（DD = 27，ID = 31，II = 3）。将DD基因型的运动员与其ID基因型的对应者进行比较。
无论其他混杂变量如何，DD基因型与ID基因型相比，左心室质量指数（LVMI）更高（162.6±36.5 g/m²对141.6±34 g/m²，p = 0.031）。因此，70.4%的DD运动员和仅42%的ID运动员符合LVH标准（p = 0.037）。尽管DD和ID受试者的收缩期和舒张早期心肌速度相似，但在调整其他生物学变量后，与ID运动员相比，DD运动员的E波减速时间（DT）更长（分别为210±48毫秒对174±36毫秒；p = 0.008）。最后，仅在DD运动员中观察到DT与心肌收缩期峰值速度（内侧和外侧峰值S[m]）之间存在正相关（p = 0.013，r = 0.481）。
无论其他已知生物学因素如何，ACE/DD基因型与耐力运动员运动诱导的LVH程度相关。
