Graduate School of Education, Hokkaido University, ; Faculty of Sports and Health Science, Fukuoka University , Fukuoka.
J Sports Sci Med. 2007 Jun 1;6(2):220-6. eCollection 2007.
Angiotensin I converting enzyme (ACE) gene Insertion / Deletion (I/D) polymorphism is associated with exercise trainability and exercise induced left ventricular hypertrophy. However, it is unclear whether this polymorphism influences exercise trainability in the elderly, and the electrocardiological alterations by exercise training is unknown among the genotypes. We herein investigated the association between ACE gene insertion/deletion (I/D) polymorphism, exercise trainability and the electrocardiological alternations by exercise in elderly women. Eighty four elderly women participated in this study. In all subjects the leg extension power (LEP) and lactate threshold (LT) were determined in order to evaluate the muscle strength, aerobic capacity and to also select the appropriate training intensity for each individual. They performed bench step exercise training for 12 weeks. A resting electrocardiogram was recorded for the obtained QTc interval in before and after the program. The baseline of aerobic capacity was higher in I/I than that in I/D, and the QTc interval was shorter in I/I than that in I/D. All other characteristics were similar among the genotypes. The QTc interval tended to be shorten only in the D/D. Furthermore, the value of the QTc interval change showed a significant difference between the I/I and D/D genotype after the program. The LT and LEP demonstrated a similar response among the genotypes. The D allele of ACE gene I/D polymorphism may therefore play a role in the electrocardiological aspect during exercise training, however, it was not found to influence the aerobic capacity. Key pointsThe D allele of ACE gene I/D polymorphism may play a role in the electrocardiological aspects during exercise trainingACE gene I/D polymorphism was not determined the aerobic capacity and leg strength in elderly people.The ACE gene I/D polymorphism did not influence aerobic and strength trainability in elderly people.
血管紧张素转换酶（ACE）基因插入/缺失（I/D）多态性与运动训练能力和运动引起的左心室肥厚有关。然而，目前尚不清楚这种多态性是否会影响老年人的运动训练能力，以及不同基因型的运动训练对心电图的影响。本研究旨在探讨 ACE 基因插入/缺失（I/D）多态性与老年女性运动训练能力、运动引起的心电图改变之间的关系。84 名老年女性参与了本研究。所有受试者均测定下肢伸肌力量（LEP）和乳酸阈（LT），以评估肌肉力量、有氧能力，并为每位受试者选择合适的训练强度。他们进行了 12 周的台阶式运动训练。在训练前后记录静息心电图以获得 QTc 间期。I/I 型的基础有氧能力高于 I/D 型，I/I 型的 QTc 间期短于 I/D 型。基因型之间的其他特征相似。仅 D/D 型的 QTc 间期有缩短趋势。此外，训练后 I/I 和 D/D 基因型之间的 QTc 间期变化值有显著差异。LT 和 LEP 在基因型之间表现出相似的反应。ACE 基因 I/D 多态性的 D 等位基因可能在运动训练期间的心电图方面发挥作用，但没有发现其影响有氧能力。关键点ACE 基因 I/D 多态性的 D 等位基因可能在运动训练期间的心电图方面发挥作用ACE 基因 I/D 多态性不能确定老年人的有氧能力和下肢力量。ACE 基因 I/D 多态性对老年人的有氧和力量训练能力没有影响。
