Chiu Yu-Hui, Lai Jiun-I, Tseng Chia-Ying, Wang Shih-Hao, Li Li-Hua, Kao Wei-Fong, How Chorng-Kuang, Chang Wen-Han, Hsieh Chin-Yi
Department of Emergency Medicine, Mackay Memorial Hospital.
Department of Emergency, School of Medicine, College of Medicine, Taipei Medical University, Taipei.
Medicine (Baltimore). 2019 Jul;98(29):e16476. doi: 10.1097/MD.0000000000016476.
The insertion (I) or deletion (D) polymorphism in the angiotension I converting enzyme gene, (ACE I/D, rs1799752) is associated with human exercise endurance and performance. However, most of the aforementioned studies focus on marathons, swimming, and triathlons, while the ACE polymorphism in ultra-marathoners has not yet been reported. We studied the impact of ACE I/D polymorphism in ultra-marathoners and investigated its relationship with lipid profiles, interleukin-6 (IL-6), and high-sensitivity C-reactive protein (hs-CRP) levels in runners before and after ultra-marathon racing.This observational study used data from a 100-km ultra-marathon in Taipei, Taiwan. Twenty-four male participants were analyzed for their ACE insertion/deletion polymorphism, lipid profiles, hs-CRP, IL-6 in serum immediately before and after ultra-marathon running.In our 24 subjects analyzed, 7, 14, and 3 subjects were of I/I, I/D, and D/D genotypes, respectively. Runners with the D polymorphism (I/D and D/D) showed a trend of better performance in the 100-km ultra-marathon (measured by completion time in minutes, P = .036). In this group, the previous best marathon performance was also significantly better than the I/I group (P = .047). After adjusting for body mass index (BMI), the difference in performance was not significant. Ketone levels, IL-6, and hs-CRP levels were highly increased at immediately and 24-hour post-race. No correlation was found between different ACE polymorphisms and common biochemical parameters examined.We report the first study in the impact of the ACE I/D (rs1799752) on ultra-marathoners. Presence of the D polymorphism in ACE gene is associated with better performance, although the BMI of the runners contribute as a major factor. There was no difference in the biochemical or lipid parameters measured among different ACE polymorphisms.
血管紧张素I转换酶基因插入（I）/缺失（D）多态性（ACE I/D，rs1799752）与人类运动耐力和表现相关。然而，上述大多数研究集中于马拉松、游泳和铁人三项，而超马拉松运动员的ACE多态性尚未见报道。我们研究了ACE I/D多态性对超马拉松运动员的影响，并调查了其与超马拉松比赛前后跑步者血脂谱、白细胞介素-6（IL-6）和高敏C反应蛋白（hs-CRP）水平的关系。这项观察性研究使用了来自台湾台北一场100公里超马拉松的数据。对24名男性参与者在超马拉松跑步前后即刻的ACE插入/缺失多态性、血脂谱、血清hs-CRP、IL-6进行了分析。
在我们分析的24名受试者中，分别有7、14和3名受试者为I/I、I/D和D/D基因型。具有D多态性的跑步者（I/D和D/D）在100公里超马拉松中表现出更好成绩的趋势（以分钟计的完成时间衡量，P = 0.036）。在该组中，之前的最佳马拉松成绩也显著优于I/I组（P = 0.047）。调整体重指数（BMI）后，成绩差异不显著。酮水平、IL-6和hs-CRP水平在赛后即刻和24小时时大幅升高。未发现不同ACE多态性与所检测的常见生化参数之间存在相关性。
我们报告了第一项关于ACE I/D（rs1799752）对超马拉松运动员影响的研究。ACE基因中D多态性的存在与更好的成绩相关，尽管跑步者的BMI是一个主要影响因素。不同ACE多态性之间所测量的生化或血脂参数没有差异。
