Denoux Y, Blanc-Vincent M P, Simony-Lafontaine J, Verriele-Beurrier V, Briffod M, Voigt J J
Centre François Baclesse, Caen.
Ann Pathol. 2003 Jun;23(3):266-78.
The Standards, Options and Recommendations (SOR) collaborative project was initiated in 1993 by the Federation of the French Cancer Centres (FNCLCC), with the 20 French Regional Cancer Centres, several French public university and general hospitals, as well as private clinics and medical speciality societies. Its main objective is the development of serviceable clinical practice guidelines in order to improve the quality of health care and the outcome of cancer patients. The methodology is based on a literature review, followed by critical appraisal by a multidisciplinary group of experts. Draft guidelines are produced, then validated by specialists in cancer care delivery.
Produce clinical practice guidelines for the management and shipment of histological and cytopathological cancer specimens using the methodology developed by the Standards, Options and Recommendations project.
The FNCLCC designated the group of experts. Available data were collected by a search of Medline and lists selected by experts in the group. A first draft of the guidelines was written, then validated by independent reviewers.
The main recommendations are: 1/ High-quality transmission of information between professionals is essential to the management of cancer specimens in order to assure high-quality diagnosis and evaluation of prognostic factors; 2/ Written procedures concerning sample shipment, handling, storage, registration, tracking and fixation exist; these procedures, as well as the necessary shipping material, will be sent to all clinical services involved; 3/ When possible, fresh, unfractionated, oriented surgical samples will be submitted to the same histological and cytopathological laboratory; 4/ Samples collected for extemporaneous examination, freezing or cell culture must be shipped immediately under appropriate storage conditions; 5/ Once frozen, samples can be stored in a deep freezer at temperatures of -80 degrees C or below, or kept in liquid nitrogen; 6/ Fixing tissues shortly after sample collection is essential to prevent cell lysis; 7/ Computerised systems will be used to assure correct specimen registration and tracking in histological and cytopathological laboratories.
标准、选项与建议（SOR）合作项目于1993年由法国癌症中心联合会（FNCLCC）发起，参与方包括20家法国地区癌症中心、几家法国公立大学及综合医院，以及私立诊所和医学专业协会。其主要目标是制定实用的临床实践指南，以提高医疗保健质量和癌症患者的治疗效果。该方法基于文献综述，随后由多学科专家小组进行批判性评估。制定指南草案，然后由癌症护理服务专家进行验证。
使用标准、选项与建议项目开发的方法，制定组织学和细胞病理学癌症标本管理与运输的临床实践指南。
FNCLCC指定了专家小组。通过检索Medline和小组专家选定的列表收集现有数据。编写了指南初稿，然后由独立评审员进行验证。
主要建议如下：1/专业人员之间高质量的信息传递对于癌症标本的管理至关重要，以确保高质量的诊断和预后因素评估；2/存在关于样本运输、处理、储存、登记、追踪和固定的书面程序；这些程序以及必要的运输材料将发送给所有相关临床服务部门；3/尽可能将新鲜、未分割、定向的手术样本提交至同一组织学和细胞病理学实验室；4/为即时检查、冷冻或细胞培养采集的样本必须在适当的储存条件下立即运输；5/一旦冷冻，样本可储存在-80摄氏度或更低温度的深冻冰箱中，或保存在液氮中；6/样本采集后尽快固定组织对于防止细胞溶解至关重要；7/将使用计算机系统确保组织学和细胞病理学实验室中样本的正确登记和追踪。
