Dale R C, Morovat A
Neurosciences Unit, Institute of Child health and Great Ormond Street Hospital NHS Trust, London, UK.
Neuropediatrics. 2003 Jun;34(3):141-5. doi: 10.1055/s-2003-41281.
Interleukin-6 (IL-6) has a number of roles including recruitment of T lymphocytes and differentiation of B lymphocytes into IgG-secreting plasma cells. Furthermore, IL-6 is a neuropoietic cytokine with effects on neuronal differentiation, function and survival. We studied IL-6 concentrations in children with acute disseminated encephalomyelitis (ADEM; n = 14), and compared the values with those obtained from control patients with other inflammatory (OIND; n = 13) and non-inflammatory (NIND; n = 10) neurological disorders. Patients with ADEM had a significantly increased CSF IL-6 concentration compared with both OIND and NIND groups ( P < 0.01). Serum IL-6 was also increased in the ADEM group compared with the OIND group ( P < 0.05). CSF: serum IL-6 ratios were significantly increased in the ADEM group compared with the NIND group ( P < 0.05), suggesting an intrathecal production of IL-6 rather than its passive transfer across the blood-brain barrier alone. In ADEM, there was a significant correlation between an increased CSF IL-6 and an identical pattern of oligoclonal IgG synthesis in both serum and CSF ( P < 0.05). These results would suggest a role for IL-6 in the pathology of ADEM, and a possible direct link between an increased IL-6 and a proliferation of B lymphocytes with consequent IgG production.
白细胞介素-6（IL-6）具有多种作用，包括募集T淋巴细胞以及促使B淋巴细胞分化为分泌IgG的浆细胞。此外，IL-6是一种神经营养细胞因子，对神经元的分化、功能及存活均有影响。我们研究了急性播散性脑脊髓炎（ADEM；n = 14）患儿的IL-6浓度，并将这些值与其他炎症性（OIND；n = 13）和非炎症性（NIND；n = 10）神经系统疾病的对照患者所测得的值进行比较。与OIND组和NIND组相比，ADEM患者的脑脊液IL-6浓度显著升高（P < 0.01）。与OIND组相比，ADEM组的血清IL-6也有所升高（P < 0.05）。与NIND组相比，ADEM组的脑脊液：血清IL-6比值显著升高（P < 0.05），这表明IL-6是鞘内产生的，而非仅通过血脑屏障被动转运。在ADEM中，脑脊液IL-6升高与血清和脑脊液中寡克隆IgG合成的相同模式之间存在显著相关性（P < 0.05）。这些结果提示IL-6在ADEM的病理过程中发挥作用，并且IL-6升高与B淋巴细胞增殖及随后的IgG产生之间可能存在直接联系。
