[鼻咽癌患者外周血淋巴细胞染色体畸变的研究]
[Study on the chromosome aberration of peripheral blood lymphocytes in patients with nasopharyngeal carcinoma].
作者信息
Gao Chunsheng, Xia Fuzhen
机构信息
Department of Otorhinolaryngology, Nanshang Hospital, Shenzhen 518052, China.
出版信息
Sichuan Da Xue Xue Bao Yi Xue Ban. 2003 Jul;34(3):489-90.
OBJECTIVE
To study the peripheral lymphocyte chromosome aberration in the patients with nasopharyngeal carcinoma.
METHODS
The peripheral blood lymphocytes, from 28 patients with nasopharyngeal carcinoma and 20 normal controls were cultured with TC199 medium for this study on chromosome aberration.
RESULTS
The chromosome number aberration rate, structure aberration rate, micronucleus rate and cell aberration rate of the peripheral lymphocytes from the patients with nasopharyngeal carcinoma were 8.68%, 10.89%, 1.83% and 8.65%, and these rates were significantly higher than those of normal controls, respectively (P < 0.05 or P < 0.01).
CONCLUSION
The above findings demonstrated the instability of chromosomes in the peripheral blood lymphocytes of nasopharyngeal carcinoma patients.
目的
研究鼻咽癌患者外周血淋巴细胞染色体畸变情况。
方法
采用TC199培养基培养28例鼻咽癌患者及20例正常对照者的外周血淋巴细胞，进行染色体畸变研究。
结果
鼻咽癌患者外周血淋巴细胞的染色体数目畸变率、结构畸变率、微核率及细胞畸变率分别为8.68%、10.89%、1.83%和8.65%，均显著高于正常对照者（P<0.05或P<0.01）。
结论
上述结果表明鼻咽癌患者外周血淋巴细胞染色体具有不稳定性。
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